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AuthorYeung, Long Yudc.contributor.author
AuthorRayudu, Nithin Manohardc.contributor.author
AuthorLöffler, Maximiliandc.contributor.author
AuthorSekuboyina, Anjanydc.contributor.author
AuthorBurian, Egondc.contributor.author
AuthorSollmann, Nicodc.contributor.author
AuthorDieckmeyer, Michaeldc.contributor.author
AuthorGreve, Tobiasdc.contributor.author
AuthorKirschke, Jan S.dc.contributor.author
AuthorSubburaj, Karupppasamydc.contributor.author
AuthorBaum, Thomasdc.contributor.author
Date of accession2022-06-27T12:41:04Zdc.date.accessioned
Available in OPARU since2022-06-27T12:41:04Zdc.date.available
Date of first publication2021-01-30dc.date.issued
AbstractTo investigate whether finite element (FE) analysis of the spine in routine thoracic/abdominal multi-detector computed tomography (MDCT) can predict incidental osteoporotic fractures at vertebral-specific level; Baseline routine thoracic/abdominal MDCT scans of 16 subjects (8(m), mean age: 66.1 ± 8.2 years and 8(f), mean age: 64.3 ± 9.5 years) who sustained incidental osteoporotic vertebral fractures as confirmed in follow-up MDCTs were included in the current study. Thoracic and lumbar vertebrae (T5-L5) were automatically segmented, and bone mineral density (BMD), finite element (FE)-based failure-load, and failure-displacement were determined. These values of individual vertebrae were normalized globally (g), by dividing the absolute value with the average of L1-3 and locally by dividing the absolute value with the average of T5-12 and L1-5 for thoracic and lumbar vertebrae, respectively. Mean-BMD of L1-3 was determined as reference. Receiver operating characteristics (ROC) and area under the curve (AUC) were calculated for different normalized FE (Kload, Kdisplacement,K(load)g, and K(displacement)g) and BMD (KBMD, and K(BMD)g) ratio parameter combinations for identifying incidental fractures. Kload, K(load)g, KBMD, and K(BMD)g showed significantly higher discriminative power compared to standard mean BMD of L1-3 (BMDStandard) (AUC = 0.67 for Kload; 0.64 for K(load)g; 0.64 for KBMD; 0.61 for K(BMD)g vs. 0.54 for BMDStandard). The combination of Kload, Kdisplacement, and KBMD increased the AUC further up to 0.77 (p < 0.001). The combination of FE with BMD measurements derived from routine thoracic/abdominal MDCT allowed an improved prediction of incidental fractures at vertebral-specific level.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordincidental vertebral fracturedc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHFinite element analysisdc.subject.mesh
MeSHMultidetector computed tomographydc.subject.mesh
MeSHOsteoporosisdc.subject.mesh
MeSHSpinedc.subject.mesh
MeSHSpinal fracturesdc.subject.mesh
TitlePrediction of incidental osteoporotic fractures at vertebral-specific level using 3D non-linear finite element parameters derived from routine abdominal MDCTdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2021-02-04T03:03:37Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-43529dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-43605-9dc.identifier.urn
GNDFinite-Elemente-Methodedc.subject.gnd
GNDMehrzeilendetektorcomputertomographiedc.subject.gnd
GNDOsteoporosedc.subject.gnd
GNDWirbelbruchdc.subject.gnd
InstitutionUKU. Klinik für diagnostische und interventionelle Radiologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withSingapore University of Technology and Designuulm.cooperation
In cooperation withTechnische Universität Münchenuulm.cooperation
In cooperation withLudwig-Maximilians-Universität Münchenuulm.cooperation
DOI of original publication10.3390/diagnostics11020208dc.relation1.doi
Source - Title of sourceDiagnosticssource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume11source.volume
Source - Issue2source.issue
Source - Year2021source.year
Source - Article number208source.articleNumber
Source - eISSN2075-4418source.identifier.eissn
Open AccessDOAJ Gold, Green Publisheduulm.OA
WoS000622476500001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.mdpi.com/2075-4418/11/2/208/s1dc.relation.isSupplementedBy
DFG project uulmIndividualisierte Risikoabschätzung von osteoporotischen Wirbelkörperfrakturen mittels Quantitativer CT im Niedrigdosisbereich und in CT-Untersuchungen aus der klinischen Routine / DFG / 432290010uulm.projectDFG


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