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Prediction of incidental osteoporotic fractures at vertebral-specific level using 3D non-linear finite element parameters derived from routine abdominal MDCT

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peer-reviewed

Erstveröffentlichung
2021-01-30
Authors
Yeung, Long Yu
Rayudu, Nithin Manohar
Löffler, Maximilian
Sekuboyina, Anjany
Burian, Egon
et al.
Wissenschaftlicher Artikel


Published in
Diagnostics ; 11 (2021), 2. - Art.-Nr. 208. - eISSN 2075-4418
Link to original publication
https://dx.doi.org/10.3390/diagnostics11020208
Institutions
UKU. Klinik für diagnostische und interventionelle Radiologie
External cooperations
Singapore University of Technology and Design
Technische Universität München
Ludwig-Maximilians-Universität München
Document version
published version (publisher's PDF)
Abstract
To investigate whether finite element (FE) analysis of the spine in routine thoracic/abdominal multi-detector computed tomography (MDCT) can predict incidental osteoporotic fractures at vertebral-specific level; Baseline routine thoracic/abdominal MDCT scans of 16 subjects (8(m), mean age: 66.1 ± 8.2 years and 8(f), mean age: 64.3 ± 9.5 years) who sustained incidental osteoporotic vertebral fractures as confirmed in follow-up MDCTs were included in the current study. Thoracic and lumbar vertebrae (T5-L5) were automatically segmented, and bone mineral density (BMD), finite element (FE)-based failure-load, and failure-displacement were determined. These values of individual vertebrae were normalized globally (g), by dividing the absolute value with the average of L1-3 and locally by dividing the absolute value with the average of T5-12 and L1-5 for thoracic and lumbar vertebrae, respectively. Mean-BMD of L1-3 was determined as reference. Receiver operating characteristics (ROC) and area under the curve (AUC) were calculated for different normalized FE (Kload, Kdisplacement,K(load)g, and K(displacement)g) and BMD (KBMD, and K(BMD)g) ratio parameter combinations for identifying incidental fractures. Kload, K(load)g, KBMD, and K(BMD)g showed significantly higher discriminative power compared to standard mean BMD of L1-3 (BMDStandard) (AUC = 0.67 for Kload; 0.64 for K(load)g; 0.64 for KBMD; 0.61 for K(BMD)g vs. 0.54 for BMDStandard). The combination of Kload, Kdisplacement, and KBMD increased the AUC further up to 0.77 (p < 0.001). The combination of FE with BMD measurements derived from routine thoracic/abdominal MDCT allowed an improved prediction of incidental fractures at vertebral-specific level.
DFG Project THU
Individualisierte Risikoabschätzung von osteoporotischen Wirbelkörperfrakturen mittels Quantitativer CT im Niedrigdosisbereich und in CT-Untersuchungen aus der klinischen Routine / DFG / 432290010
Is supplemented by
https://www.mdpi.com/2075-4418/11/2/208/s1
Subject headings
[GND]: Finite-Elemente-Methode | Mehrzeilendetektorcomputertomographie | Osteoporose | Wirbelbruch
[MeSH]: Finite element analysis | Multidetector computed tomography | Osteoporosis | Spine | Spinal fractures
[Free subject headings]: incidental vertebral fracture
[DDC subject group]: DDC 610 / Medicine & health
License
CC BY 4.0 International
https://creativecommons.org/licenses/by/4.0/

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-43529

Yeung, Long Yu et al. (2022): Prediction of incidental osteoporotic fractures at vertebral-specific level using 3D non-linear finite element parameters derived from routine abdominal MDCT. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-43529
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