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AuthorLópez-Gil, Juan Carlosdc.contributor.author
AuthorMartin-Hijano, Lauradc.contributor.author
AuthorHermann, Patrick C.dc.contributor.author
AuthorSainz, Brunodc.contributor.author
Date of accession2022-06-27T12:28:43Zdc.date.accessioned
Available in OPARU since2022-06-27T12:28:43Zdc.date.available
Date of first publication2021-01-26dc.date.issued
AbstractCancer stem cells (CSCs) are defined as a subpopulation of “stem”-like cells within the tumor with unique characteristics that allow them to maintain tumor growth, escape standard anti-tumor therapies and drive subsequent repopulation of the tumor. This is the result of their intrinsic “stem”-like features and the strong driving influence of the CSC niche, a subcompartment within the tumor microenvironment that includes a diverse group of cells focused on maintaining and supporting the CSC. CXCL12 is a chemokine that plays a crucial role in hematopoietic stem cell support and has been extensively reported to be involved in several cancer-related processes. In this review, we will provide the latest evidence about the interactions between CSC niche-derived CXCL12 and its receptors—CXCR4 and CXCR7—present on CSC populations across different tumor entities. The interactions facilitated by CXCL12/CXCR4/CXCR7 axes seem to be strongly linked to CSC “stem”-like features, tumor progression, and metastasis promotion. Altogether, this suggests a role for CXCL12 and its receptors in the maintenance of CSCs and the components of their niche. Moreover, we will also provide an update of the therapeutic options being currently tested to disrupt the CXCL12 axes in order to target, directly or indirectly, the CSC subpopulation.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordcancer stem cellsdc.subject
KeywordCSC nichedc.subject
KeywordCXCR4dc.subject
KeywordCXCR4 inhibitorsdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHNeoplastic stem cellsdc.subject.mesh
MeSHReceptors, CXCR4dc.subject.mesh
MeSHChemokinesdc.subject.mesh
TitleThe CXCL12 crossroads in cancer stem cells and their nichedc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2021-02-03T23:30:29Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-43528dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-43604-3dc.identifier.urn
GNDTumordc.subject.gnd
GNDStammzelledc.subject.gnd
GNDChemokin CXCL12dc.subject.gnd
InstitutionUKU. Klinik für Innere Medizin Iuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withUniversidad Autónoma de Madriduulm.cooperation
DOI of original publication10.3390/cancers13030469dc.relation1.doi
Source - Title of sourceCancerssource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume13source.volume
Source - Issue3source.issue
Source - Year2021source.year
Source - Article number489source.articleNumber
Source - eISSN2072-6694source.identifier.eissn
Open AccessDOAJ Gold, Green Publisheduulm.OA
WoS000614986300001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
DFG project uulmSFB 1279 / Nutzung des menschlichen Peptidoms für die Entwicklung neuer antimikrobieller und anti-Krebs Therapeutika / DFG / 316249678uulm.projectDFG
Project uulmM65.1: Circulating cancer stem cells as a new predictive biomarker for treatment response and metastasis in pancreatic cancer / Hector Stiftung / M65.1uulm.projectOther


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