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The CXCL12 crossroads in cancer stem cells and their niche

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cancers-13-00469-v2. ... (1.171Mb)

peer-reviewed

Erstveröffentlichung
2021-01-26
Authors
López-Gil, Juan Carlos
Martin-Hijano, Laura
Hermann, Patrick C.
Sainz, Bruno
Wissenschaftlicher Artikel


Published in
Cancers ; 13 (2021), 3. - Art.-Nr. 489. - eISSN 2072-6694
Link to original publication
https://dx.doi.org/10.3390/cancers13030469
Institutions
UKU. Klinik für Innere Medizin I
External cooperations
Universidad Autónoma de Madrid
Document version
published version (publisher's PDF)
Abstract
Cancer stem cells (CSCs) are defined as a subpopulation of “stem”-like cells within the tumor with unique characteristics that allow them to maintain tumor growth, escape standard anti-tumor therapies and drive subsequent repopulation of the tumor. This is the result of their intrinsic “stem”-like features and the strong driving influence of the CSC niche, a subcompartment within the tumor microenvironment that includes a diverse group of cells focused on maintaining and supporting the CSC. CXCL12 is a chemokine that plays a crucial role in hematopoietic stem cell support and has been extensively reported to be involved in several cancer-related processes. In this review, we will provide the latest evidence about the interactions between CSC niche-derived CXCL12 and its receptors—CXCR4 and CXCR7—present on CSC populations across different tumor entities. The interactions facilitated by CXCL12/CXCR4/CXCR7 axes seem to be strongly linked to CSC “stem”-like features, tumor progression, and metastasis promotion. Altogether, this suggests a role for CXCL12 and its receptors in the maintenance of CSCs and the components of their niche. Moreover, we will also provide an update of the therapeutic options being currently tested to disrupt the CXCL12 axes in order to target, directly or indirectly, the CSC subpopulation.
DFG Project THU
SFB 1279 / Nutzung des menschlichen Peptidoms für die Entwicklung neuer antimikrobieller und anti-Krebs Therapeutika / DFG / 316249678
Project uulm
M65.1: Circulating cancer stem cells as a new predictive biomarker for treatment response and metastasis in pancreatic cancer / Hector Stiftung / M65.1
Subject headings
[GND]: Tumor | Stammzelle | Chemokin CXCL12
[MeSH]: Neoplastic stem cells | Receptors, CXCR4 | Chemokines
[Free subject headings]: cancer stem cells | CSC niche | CXCR4 | CXCR4 inhibitors
[DDC subject group]: DDC 610 / Medicine & health
License
CC BY 4.0 International
https://creativecommons.org/licenses/by/4.0/

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-43528

López-Gil, Juan Carlos et al. (2022): The CXCL12 crossroads in cancer stem cells and their niche. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-43528
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