NeuroExercise: The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment—A Multicenter Randomized Controlled Trial
Sanders, Marit L.
Devenney, Kate E.
Aaronson, Justine A.
Frontiers in Aging Neuroscience ; 12 (2021). - Art.-Nr. 621947.. - eISSN 1663-4365
Link to original publicationhttps://dx.doi.org/10.3389/fnagi.2020.621947
FacultiesFakultät für Ingenieurwissenschaften, Informatik und Psychologie
InstitutionsInstitut für Psychologie und Pädagogik
Document versionpublished version (publisher's PDF)
Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(−0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [−1.76 (−3.39, −0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO2peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02913053, identifier: NCT02913053.
Is supplemented byhttps://www.frontiersin.org/articles/10.3389/fnagi.2020.621947/full#supplementary-material
Subject headings[GND]: Alzheimerkrankheit | Kognition | Alternative Medizin | Lebensqualität
[MeSH]: Alzheimer disease | Cognition | Cognitive dysfunction | Complementary therapies | Exercise | Quality of life
[Free subject headings]: Alzheimer's disease | non-pharmacological treatment | aerobic exercise
[DDC subject group]: DDC 150 / Psychology | DDC 610 / Medicine & health
LicenseCC BY 4.0 International
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DOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-43427