A novel pulsatile blood pump design for cardiothoracic surgery - proof-of-concept in a mock circulation

Erstveröffentlichung
2022-05-06Data creator
Weber, Elena
Liebold, Andreas
Hönicka, Markus
Forschungsdaten
Faculties
Medizinische FakultätInstitutions
UKU. Klinik für Herz-, Thorax- und GefäßchirurgieExternal cooperations
Triphasic Cardiac Pump Pty Ltd, Nedlands, WA, AustraliaAbstract
Pulsatile perfusion during extracorporeal circulation is a promising concept to improve perfusion of critical organs. Clinical benefits are limited by the amount of pulsatile energy provided by standard pumps. We investigated the properties of a novel positive displacement blood pump in a mock circulation containing an aortic model with a human-like geometry and compliance as a pseudo patient. Using a regular oxygenator, maximum flow was 2.6 L/min at a pressure of 27 mmHg and a frequency (F) of 90 bpm. Pulse pressure (PP; 28.9 mmHg) and surplus hemodynamic energy (SHE; 26.1% of mean arterial pressure) were highest at F=40 bpm. Flow and pressure profiles appeared sinusoid. Using a low-resistance membrane ventilator to assess the impact of back pressure, maximum flow was 4.0 L/min at a pressure of 58.6 mmHg and F=40 bpm. At F=40 bpm, PP was 58.7 mmHg with an SHE of 33.4%. SHE decreased with increasing flow, heart rate, and systolic percentage but surpassed 10% with reasonable settings. The present prototype achieved sufficient flow and pressure ranges only in the presence of a low-resistance membrane ventilator. It delivered supraphysiologic levels of pulse pressure and SHE. Further modifications will help to establish this concept for adult pulsatile perfusion.
Date created
2021-07/2021-08
Is supplement to
http://dx.doi.org/10.18725/OPARU-47343Subject headings
[GND]: Aortendruck[LCSH]: Blood pressure
[MeSH]: Extracorporeal Circulation | Pulsatile Flow
[Free subject headings]: blood pump | pulsatile perfusion | surplus hemodynamic energy | pulsatility index
[DDC subject group]: DDC 610 / Medicine & health | DDC 620 / Engineering & allied operations
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Show full item recordDOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-42997
Weber, Elena; Liebold, Andreas; Hönicka, Markus (2022): A novel pulsatile blood pump design for cardiothoracic surgery - proof-of-concept in a mock circulation. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-42997
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