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AuthorHeller, Sandradc.contributor.author
AuthorLi, Zhijiandc.contributor.author
AuthorLin, Qiongdc.contributor.author
AuthorGeusz, Ryandc.contributor.author
AuthorBreunig, Markusdc.contributor.author
AuthorHohwieler, Meikedc.contributor.author
AuthorZhang, Xidc.contributor.author
AuthorNair, Gopika G.dc.contributor.author
AuthorSeufferlein, Thomasdc.contributor.author
AuthorHebrok, Matthiasdc.contributor.author
AuthorSander, Maikedc.contributor.author
AuthorJulier, Céciledc.contributor.author
AuthorKleger, Alexanderdc.contributor.author
AuthorCosta Filho, Ivan Gesteiradc.contributor.author
Date of accession2022-04-04T08:33:34Zdc.date.accessioned
Available in OPARU since2022-04-04T08:33:34Zdc.date.available
Date of first publication2021-11-17dc.date.issued
AbstractCell type specification during pancreatic development is tightly controlled by a transcriptional and epigenetic network. The precise role of most transcription factors, however, has been only described in mice. To convey such concepts to human pancreatic development, alternative model systems such as pancreatic in vitro differentiation of human pluripotent stem cells can be employed. Here, we analyzed stage-specific RNA-, ChIP-, and ATAC-sequencing data to dissect transcriptional and regulatory mechanisms during pancreatic development. Transcriptome and open chromatin maps of pancreatic differentiation from human pluripotent stem cells provide a stage-specific pattern of known pancreatic transcription factors and indicate ONECUT1 as a crucial fate regulator in pancreas progenitors. Moreover, our data suggest that ONECUT1 is also involved in preparing pancreatic progenitors for later endocrine specification. The dissection of the transcriptional and regulatory circuitry revealed an important role for ONECUT1 within such network and will serve as resource to study human development and disease.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordDifferentiationdc.subject
KeywordHigh-throughput screeningdc.subject
KeywordStem-cell differentiationdc.subject
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
LCSHRegenerative medicinedc.subject.lcsh
LCSHStem cellsdc.subject.lcsh
MeSHPluripotent stem cellsdc.subject.mesh
MeSHTissue engineeringdc.subject.mesh
MeSHPancreasdc.subject.mesh
MeSHTranscription, Geneticdc.subject.mesh
TitleTranscriptional changes and the role of ONECUT1 in hPSC pancreatic differentiationdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-42720dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-42796-0dc.identifier.urn
GNDRegenerative Medizindc.subject.gnd
GNDInduzierte pluripotente Stammzelledc.subject.gnd
InstitutionUKU. Klinik für Innere Medizin Iuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withRWTH Aachenuulm.cooperation
In cooperation withBayer AGuulm.cooperation
In cooperation withUniversity of Californiauulm.cooperation
In cooperation withUniversité de Parisuulm.cooperation
DOI of original publication10.1038/s42003-021-02818-3dc.relation1.doi
Source - Title of sourceCommunications Biologysource.title
Source - Place of publicationNature Researchsource.publisher
Source - Volume4source.volume
Source - Year2021source.year
Source - Article number1298source.articleNumber
Source - eISSN2399-3642source.identifier.eissn
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.nature.com/articles/s42003-021-02818-3#Sec21dc.relation.isSupplementedBy
DFG project uulmGRK 2254 / HEIST / Heterogenität und Evolution in soliden Tumoren (HEIST) / DFG / 288342734 [KL 2544/1-2]uulm.projectDFG
DFG project uulmZelluläre Plastizität im Pankreas - vom Krankheitsmodell über Gewebserneuerung zur personalisierten Medizin / DFG / 426789149 [KL 2544/7-1]uulm.projectDFG
DFG project uulmMonogenetische Formen des juvenil sich manifestierenden Diabetes: neue Schritte in Richtung β-Zellentwicklung, -funktion und -überleben / DFG / 406674944uulm.projectDFG
Project uulmBIU / Boehringer Ingelheim Ulm University BioCenter (BIU) / Forschungsverbunduulm.projectOther
xmlui.metadata.uulm.OAfundingOpen-Access-Förderung durch die Medizinische Fakultät der Universität Ulmuulm.OAfunding


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