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AuthorErmakova, Annadc.contributor.author
Date of accession2017-02-01T12:06:04Zdc.date.accessioned
Available in OPARU since2017-02-01T12:06:04Zdc.date.available
Year of creation2016dc.date.created
Date of first publication2017-02-01dc.date.issued
AbstractThis thesis is dedicated to applications of nanodiamonds with colour centres for imaging and magnetic field sensing. Diamond nanocrystals with optically active defects such as nitrogen-vacancy (NV) or silicon-vacancy (SiV) can be used as optical markers. They are characterized by highly stable emission in contrast to other known optical markers. Owing to this they are attractive for studies of biological systems. First part of this thesis demonstrates application of nanodiamonds for drug delivery process. Stabilization of the nanocrystal’s surface in different solutions was achieved by coating with HSA-protein. Utilizing protein-protected nanodiamonds as carriers for chemotherapy drug (Doxorubicin), targeted delivery to the acidic tumor was demonstrated. Pre-clinical test proved the effectivity of this method compared to free drug molecules. The negatively charged nitrogen-vacancy centre due to unique combination of its optical and spin properties can be used as an atomic scale magnetic sensor. It combines in one high sensitivity and high resolution. In second part of this thesis these properties are exploited for detection of the metallo-protein – ferritin. The measurements of spin relaxation times allow to reveal the presence of ferritin in close vicinity of NV centre. The demonstrated experiments pave the way to a new method of ferritin’s core investigation, which is invaluable for diagnostics of different diseases.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordDrug deliverydc.subject
KeywordNitrogen-vacancy centredc.subject
KeywordSpin sensingdc.subject
Dewey Decimal GroupDDC 530 / Physicsdc.subject.ddc
LCSHDiamondsdc.subject.lcsh
LCSHBiochemical markersdc.subject.lcsh
LCSHMagnetometersdc.subject.lcsh
LCSHDrug delivery systemsdc.subject.lcsh
LCSHNanodiamondsdc.subject.lcsh
TitleSingle spins in diamond for nanoscale sensing and microscopydc.title
Resource typeDissertationdc.type
Date of acceptance2016-11-09dcterms.dateAccepted
RefereeJelezko, Fedordc.contributor.referee
RefereeNaydenov, Borisdc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-4215dc.identifier.doi
PPN878945695dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-4254-4dc.identifier.urn
GNDDiamantdc.subject.gnd
GNDBiomarkerdc.subject.gnd
GNDMagnetometerdc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
InstitutionInstitut für Quantenoptikuulm.affiliationSpecific
Shelfmark print versionW: W-H 14.981uulm.shelfmark
Grantor of degreeFakultät für Naturwissenschaftenuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
TypeErstveröffentlichunguulm.veroeffentlichung
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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