Optimizing manufacturing and osseointegration of Ti6Al4V implants through precision casting and calcium and phosphorus ion implantation? In vivo results of a large-scale animal trial
peer-reviewed
Erstveröffentlichung
2020-04-03Authors
JV, Wölfle-Roos
B, Katmer Amet
J, Fiedler
H, Michels
G, Kappelt
Wissenschaftlicher Artikel
Published in
Materials ; 13 (2020), 7. - Art.-Nr. 1670. - eISSN 1996-1944
Link to original publication
https://dx.doi.org/10.3390/ma13071670Institutions
UKU. Institut für Unfallchirurgische Forschung und BiomechanikUKU. Klinik für Orthopädie
External cooperations
Access TechnologyPeter Brehm GmbH
Document version
published version (publisher's PDF)Abstract
Background: Uncemented implants are still associated with several major challenges, especially with regard to their manufacturing and their osseointegration. In this study, a novel manufacturing technique—an optimized form of precision casting—and a novel surface modification to promote osseointegration—calcium and phosphorus ion implantation into the implant surface—were tested in vivo. Methods: Cylindrical Ti6Al4V implants were inserted bilaterally into the tibia of 110 rats. We compared two generations of cast Ti6Al4V implants (CAST 1st GEN, n = 22, and CAST 2nd GEN, n = 22) as well as cast 2nd GEN Ti6Al4V implants with calcium (CAST + CA, n = 22) and phosphorus (CAST + P, n = 22) ion implantation to standard machined Ti6Al4V implants (control, n = 22). After 4 and 12 weeks, maximal pull-out force and bone-to-implant contact rate (BIC) were measured and compared between all five groups. Results: There was no significant difference between all five groups after 4 weeks or 12 weeks with regard to pull-out force (p > 0.05, Kruskal Wallis test). Histomorphometric analysis showed no significant difference of BIC after 4 weeks (p > 0.05, Kruskal–Wallis test), whereas there was a trend towards a higher BIC in the CAST + P group (54.8% ± 15.2%), especially compared to the control group (38.6% ± 12.8%) after 12 weeks (p = 0.053, Kruskal–Wallis test). Conclusion: In this study, we found no indication of inferiority of Ti6Al4V implants cast with the optimized centrifugal precision casting technique of the second generation compared to standard Ti6Al4V implants. As the employed manufacturing process holds considerable economic potential, mainly due to a significantly decreased material demand per implant by casting near net-shape instead of milling away most of the starting ingot, its application in manufacturing uncemented implants seems promising. However, no significant advantages of calcium or phosphorus ion implantation could be observed in this study. Due to the promising results of ion implantation in previous in vitro and in vivo studies, further in vivo studies with different ion implantation conditions should be considered.
Project uulm
OSTEOFIT / KMU-Innovativ - Verbundprojekt: Verschleißarmes knocheninduktives Knieimplantatsystem auf Basis Titan (OSTEOFIT) - Teilvorhaben: Biokompatibilität und Osseointegration / BMBF / 13GW0020E
Subject headings
[GND]: Ionenimplantation | Wachsausschmelzungsverfahren | TiAl6V4 | Phosphor | Schleuderguss[LCSH]: Ion implantation | Precision casting | Calcium | Phosphorus | Centrifugal casting
[Free subject headings]: Ti6Al4V
[DDC subject group]: DDC 570 / Life sciences
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-42303
JV, Wölfle-Roos et al. (2022): Optimizing manufacturing and osseointegration of Ti6Al4V implants through precision casting and calcium and phosphorus ion implantation? In vivo results of a large-scale animal trial. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-42303
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