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AuthorSteiner, Silkedc.contributor.author
Date of accession2016-12-07T10:27:53Zdc.date.accessioned
Available in OPARU since2016-12-07T10:27:53Zdc.date.available
Year of creation2015dc.date.created
Date of first publication2016-12-07dc.date.issued
AbstractIs (99m)Tc–sestamibi scintigraphy able to predict malignancy of thyroid nodules? Objective: A differentiation between benign and malignant thyroid nodules is a common issue for preoperative decision making in patients subjected to thyroid surgery. The aim of this study was to determine whether (99m)Tc-sestamibi scintigraphy was able to identifiy differentiated thyroid carcinoma. Methods: A prospective database was reviewed to identify 57 patients (72 % female, 28 % male, mean age 57.6 years) with thyroid nodules and preoperative (99m)Tc-sestamibi scintigraphy for primary hyperparathyroidism (32 %) and/or suspicious thyroid nodules. Results: In 39 patients a thyroid lobectomy was performed. In 1 patient a nodule enucleation was done. 17 patients underwent near-total or total thyroidectomy, 6 of them an additional prophylactic central lymph node dissection. In 82,5 % benign thyroid disease was detected, in 17,5 % histopathology described thyroid malignancies (9 PTC, 1 FTC). The mean tumor size was 1.5 cm. The sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of (99m)Tc-sestamibi scintigraphy for the diagnosis of thyroid malignancy were 90.0 %, 36.2 %, 23.1 % and, 94.4 %. False-negative results were only noticed for 1 papillary microcarcinoma of 0.4 cm diameter. Conclusions: (99m)Tc-sestamibi scintigraphy has a high negative predictive value and may therefore lead to a higher rate of thyroid nodules that can be followed. Sestamibi positive lesions should be strongly considered for thyroid surgery.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordMIBI-Szintigraphiedc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHThyroid glanddc.subject.mesh
MeSHThyroid noduledc.subject.mesh
MeSHTechnetium Tc 99m sestamibidc.subject.mesh
TitleDie (99m)Technetium-Methoxy-Isobutyl-Isonitril (MIBI)-Szintigraphie als präoperatives diagnostisches Verfahren zur Beurteilung der Dignität von Schilddrüsenknotendc.title
Resource typeDissertationdc.type
Date of acceptance2016-11-18dcterms.dateAccepted
RefereeWeber, Theresiadc.contributor.referee
RefereeBeer, Ambrosdc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-4160dc.identifier.doi
PPN874224845dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-4199-6dc.identifier.urn
GNDSchilddrüsedc.subject.gnd
GNDSchilddrüsenszintigraphiedc.subject.gnd
GNDStrumaknotendc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Klinik für Nuklearmedizinuulm.affiliationSpecific
InstitutionUKU. Klinik für Allgemein- und Viszeralchirurgieuulm.affiliationSpecific
Shelfmark print versionW: W-H 14.940uulm.shelfmark
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
TypeErstveröffentlichunguulm.veroeffentlichung
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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