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AuthorKroll, Christinedc.contributor.author
Date of accession2016-08-08T09:41:19Zdc.date.accessioned
Available in OPARU since2016-08-08T09:41:19Zdc.date.available
Year of creation2015dc.date.created
Date of first publication2016-08-08dc.date.issued
AbstractBACKGROUND: Iron supplementation is generally recommended for blood donors even though there are inter-individual differences in iron homeostasis. METHODS: Ferritin levels of repeat donors were compared with first-time donors, retrospectively. Prospectively, we tested 27 male repeat donors for the following parameters at the day of blood donation as well as 1, 3, 7, 10, and 56 days thereafter: ferritin, hepcidin, transferrin, transferrin receptor, hemoglobin, erythropoietin, reticulocytes, hemoglobin in reticulocyte, twisted gastrulation protein homolog 1, and growth differentiation factor-15. RESULTS: 56 days after blood donation, donors' average ferritin dropped to 55% (range 30-100%) compared to the initial value. Of all tested parameters hepcidin showed the highest and most significant changes beginning 1 day after donation and lasting for the whole period of 56 days. Along with ferritin, there was a high variation in hepcidin levels indicating inter-individual differences in hepcidin response to iron loss. Donors with a hepcidin/ferritin quotient < 0.3 regained 60% of their initial ferritin after 56 days, while those with a quotient ≥ 0.3 reached less than 50%. CONCLUSION: As hepcidin appears to integrate erythropoietic and iron-loading signals, clinical measurement of hepcidin (together with the hepcidin-ferritin ratio) may become a useful indicator of erythropoiesis and iron kineticsdc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHBlood donorsdc.subject.mesh
MeSHAnemia, iron-deficiencydc.subject.mesh
MeSHFerritinsdc.subject.mesh
TitleHepcidin-Ferritin-Quotient als Vorhersageprädiktor für die spontane Regeneration des Eisenverlustes nach einer Blutspendedc.title
Resource typeDissertationdc.type
Date of acceptance2016-07-07dcterms.dateAccepted
RefereeLotfi, Ramindc.contributor.referee
RefereeSchneider, Mariondc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-4079dc.identifier.doi
PPN865991200dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-4118-9dc.identifier.urn
GNDBlutspendedc.subject.gnd
GNDFerritindc.subject.gnd
GNDEisenstoffwechseldc.subject.gnd
GNDEisenverlustdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Klinische Transfusionsmedizin und Immungenetik Ulm gGmbH (IKT)uulm.affiliationSpecific
InstitutionUKU. Klinik für Anästhesiologieuulm.affiliationSpecific
InstitutionUKU. Institut für Transfusionsmedizinuulm.affiliationSpecific
Shelfmark print versionW: W-H 14.821uulm.shelfmark
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
TypeErstveröffentlichunguulm.veroeffentlichung
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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