Show simple item record

AuthorSalgin, Burakdc.contributor.author
AuthorMeissner, Thomasdc.contributor.author
AuthorBeyer, Peterdc.contributor.author
AuthorHaberland, Holgerdc.contributor.author
AuthorBorkenstein, Martindc.contributor.author
AuthorFussenegger, Jörgdc.contributor.author
AuthorBrand, Ulrichdc.contributor.author
AuthorHauffa, Berthold P.dc.contributor.author
AuthorHungele, Andreasdc.contributor.author
AuthorHoll, Reinhard W.dc.contributor.author
Date of accession2021-12-06T07:16:16Zdc.date.accessioned
Available in OPARU since2021-12-06T07:16:16Zdc.date.available
Date of first publication2013-06-18dc.date.issued
AbstractBackground/Aims: Lipoatrophy (LA) is a rare, possibly under-recognised side effect of insulin treatment of unclear aetiology. The aim of this study was to describe the characteristics of patients with type 1 diabetes (T1D) who have LA and to explore the relationship between LA and other autoimmune diseases based on the hypothesis that additional autoimmune phenomena are more prevalent in T1D patients with LA. Methods: This was a cross-sectional observational study of T1D patients with LA in comparison to T1D patients without LA who are registered with the Diabetes Patienten-Verlaufsdokumentationssystem database of 241,650 patients in Germany and Austria. Results: Hashimoto's thyroiditis and coeliac disease were more prevalent in patients with LA (p < 0.001 for both). LA was associated with an increased risk of Hashimoto's thyroiditis and coeliac disease in female patients [odds ratio (OR) 2.5, p = 0.003, and OR 3.1, p = 0.02, respectively]. This relationship persisted after adjustment for current age, duration of diabetes and calendar year of treatment (OR 2.7, p = 0.002, and OR 3.5, p = 0.01, respectively). Conclusion: These findings support the hypothesis that an immune complex-mediated inflammatory process may be important in the development of LA. © In Copyright http://rightsstatements.org/vocab/InC/1.0/dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseIn Copyrightdc.rights
Link to license texthttp://rightsstatements.org/vocab/InC/1.0/dc.rights.uri
KeywordType 1 diabetesdc.subject
KeywordLipoatrophydc.subject
KeywordHashimoto’s thyroiditisdc.subject
KeywordCoeliac diseasedc.subject
KeywordDiabetes Patienten-Verlaufsdokumentationssystemdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHDiabetes mellitus, Type 1dc.subject.mesh
MeSHDrug-related side effects and adverse reactionsdc.subject.mesh
MeSHHashimoto diseasedc.subject.mesh
MeSHCeliac diseasedc.subject.mesh
TitleLipoatrophy Is Associated with an Increased Risk of Hashimoto's Thyroiditis and Coeliac Disease in Female Patients with Type 1 Diabetesdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2020-01-28T13:26:30Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-40125dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-40201-6dc.identifier.urn
GNDDiabetes mellitus Typ 1dc.subject.gnd
GNDBerardinelli-Syndromdc.subject.gnd
GNDHashimoto-Thyreoiditisdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withUniversitätsklinikum Düsseldorfuulm.cooperation
In cooperation withEvangelischen Krankenhaus Oberhausenuulm.cooperation
In cooperation withSana Klinikumuulm.cooperation
In cooperation withRKH Klinikenuulm.cooperation
In cooperation withUniversitätsklinikum Essenuulm.cooperation
In cooperation withMedizinische Universität Grazuulm.cooperation
In cooperation withKrankenhaus Dornbirnuulm.cooperation
DOI of original publication10.1159/000351708dc.relation1.doi
Source - Title of sourceHormone Research in Paediatricssource.title
Source - Place of publicationKarger Publisherssource.publisher
Source - Volume79source.volume
Source - Issue6source.issue
Source - Year2013source.year
Source - From page368source.fromPage
Source - To page372source.toPage
Source - ISSN1663-2818source.identifier.issn
Source - eISSN1663-2826source.identifier.eissn
PubMed23796529uulm.identifier.pubmed
Rights noticeDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.dc.rights.other
Rights noticeThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.dc.rights.other
Bibliographyuulmuulm.bibliographie


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record