Adoptive immunotherapy after allogeneic hematopoietic progenitor cell transplantation: new perspectives for transfusion Medicine
peer-reviewed
Erstveröffentlichung
2011-05-11Authors
Hofmann, Susanne
Greiner, Jochen
Wissenschaftlicher Artikel
Published in
Transfusion Medicine and Hemotherapy ; 38 (2011), 3. - S. 173-182. - ISSN 1660-3796. - eISSN 1660-3818
Link to original publication
https://dx.doi.org/10.1159/000328898Faculties
Medizinische FakultätInstitutions
UKU. Klinik für Innere Medizin IIIDocument version
published version (publisher's PDF)Abstract
Allogeneic hematopoietic progenitor cell transplantation (HPCT) is a crucial therapeutic option in hematological malignancies, and the graft-versus-leukemia (GvL) effect builds the cornerstone of a long-lasting remission. Cytotoxic T cells are known to be the primary effector cells in GvL. They recognize minor histocompatibility antigens (mHags) and tumor/leukemia-associated antigens. In case of disease relapse after HPCT, donor lymphocyte infusion (DLI) is an important treatment option for re-induction of remission. However, both treatments, HPCT and DLI carry the risk of morbidity and mortality due to graft-versus-host disease (GvHD) and severe infections. Therefore, the development of targeted adoptive immunotherapy with a lower risk of GvHD is needed, and several study groups are working on that topic. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Subject headings
[GND]: Transplantat-Wirt-Reaktion | Allogene Zelle | Transplantation | T-Lymphozyt[MeSH]: Stem cell transplantation | T-Lymphocytes | Graft vs host reaction
[Free subject headings]: Allogeneic stem cell transplantation | DLI | GvL | T cell
[DDC subject group]: DDC 610 / Medicine & health
Rights notice
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-40032
Hofmann, Susanne; Greiner, Jochen (2021): Adoptive immunotherapy after allogeneic hematopoietic progenitor cell transplantation: new perspectives for transfusion Medicine. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-40032
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