• English
    • Deutsch
  • English 
    • English
    • Deutsch
  • Login
View Item 
  •   Home
  • Universität Ulm / Medizin
  • Publikationen
  • View Item
  •   Home
  • Universität Ulm / Medizin
  • Publikationen
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Adoptive immunotherapy after allogeneic hematopoietic progenitor cell transplantation: new perspectives for transfusion Medicine

Thumbnail
TMH328898.pdf (221.2Kb)

peer-reviewed

Erstveröffentlichung
2011-05-11
Authors
Hofmann, Susanne
Greiner, Jochen
Wissenschaftlicher Artikel


Published in
Transfusion Medicine and Hemotherapy ; 38 (2011), 3. - S. 173-182. - ISSN 1660-3796. - eISSN 1660-3818
Link to original publication
https://dx.doi.org/10.1159/000328898
Faculties
Medizinische Fakultät
Institutions
UKU. Klinik für Innere Medizin III
Document version
published version (publisher's PDF)
Abstract
Allogeneic hematopoietic progenitor cell transplantation (HPCT) is a crucial therapeutic option in hematological malignancies, and the graft-versus-leukemia (GvL) effect builds the cornerstone of a long-lasting remission. Cytotoxic T cells are known to be the primary effector cells in GvL. They recognize minor histocompatibility antigens (mHags) and tumor/leukemia-associated antigens. In case of disease relapse after HPCT, donor lymphocyte infusion (DLI) is an important treatment option for re-induction of remission. However, both treatments, HPCT and DLI carry the risk of morbidity and mortality due to graft-versus-host disease (GvHD) and severe infections. Therefore, the development of targeted adoptive immunotherapy with a lower risk of GvHD is needed, and several study groups are working on that topic. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Subject headings
[GND]: Transplantat-Wirt-Reaktion | Allogene Zelle | Transplantation | T-Lymphozyt
[MeSH]: Stem cell transplantation | T-Lymphocytes | Graft vs host reaction
[Free subject headings]: Allogeneic stem cell transplantation | DLI | GvL | T cell
[DDC subject group]: DDC 610 / Medicine & health
Rights notice
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
 
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
License
In Copyright
http://rightsstatements.org/vocab/InC/1.0/

Metadata
Show full item record

DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-40032

Hofmann, Susanne; Greiner, Jochen (2021): Adoptive immunotherapy after allogeneic hematopoietic progenitor cell transplantation: new perspectives for transfusion Medicine. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-40032
Citation formatter >



Policy | kiz service OPARU | Contact Us
Impressum | Privacy statement
 

 

Advanced Search

Browse

All of OPARUCommunities & CollectionsPersonsInstitutionsPublication typesUlm SerialsDewey Decimal ClassesEU projects UlmDFG projects UlmOther projects Ulm

My Account

LoginRegister

Statistics

View Usage Statistics

Policy | kiz service OPARU | Contact Us
Impressum | Privacy statement