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AuthorCatanese, Albertodc.contributor.author
AuthorRajkumar, Sandeepdc.contributor.author
AuthorSommer, Danieldc.contributor.author
AuthorFreisem, Dennisdc.contributor.author
AuthorWirth, Alexanderdc.contributor.author
AuthorAly, Amrdc.contributor.author
AuthorMassa‐López, Daviddc.contributor.author
AuthorOlivieri, Andreadc.contributor.author
AuthorTorelli, Federicadc.contributor.author
AuthorIoannidis, Valentindc.contributor.author
AuthorLipecka, Joannadc.contributor.author
AuthorGuerrera, Ida Chiaradc.contributor.author
AuthorZytnicki, Danieldc.contributor.author
AuthorLudolph, Albertdc.contributor.author
AuthorKabashi, Edordc.contributor.author
AuthorMulaw, Medhanie Adc.contributor.author
AuthorRoselli, Francescodc.contributor.author
AuthorBöckers, Tobias Mdc.contributor.author
Date of accession2021-11-29T08:51:45Zdc.date.accessioned
Available in OPARU since2021-11-29T08:51:45Zdc.date.available
Date of first publication2021-06-14dc.date.issued
AbstractSynopsis image The lack of an effective treatment for ALS is calling for the development of novel therapeutic strategies. By using hiPSC‐derived motoneurons and focusing on synapse‐related processes, we provide new molecular targets rescuing the degenerative processes and neuronal loss in ALS. Human C9orf72‐mutant motoneurons are characterized by reduced expression of synaptic gene, progressive loss of CREB activity and synapse loss. Similar alterations are observed also in motoneurons harboring TBK1 pathogenic mutations, and in primary neurons upon overexpression of poly(GA) aggregates. The K+ channel blockers Apamin and XE991 revert the CREB‐dependent loss of synaptic contacts and rescue the degenerative phenotypes of ALS motoneurons.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordALSdc.subject
KeywordCREBdc.subject
KeywordhiPSCdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAmyotrophic lateral sclerosis; Therapydc.subject.mesh
MeSHMotor neuronsdc.subject.mesh
MeSHSynapsesdc.subject.mesh
TitleSynaptic disruption and CREB‐regulated transcription are restored by K+ channel blockers in ALSdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2021-09-08T12:28:20Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-40024dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-40100-4dc.identifier.urn
GNDMyatrophische Lateralsklerosedc.subject.gnd
GNDMotoneurondc.subject.gnd
GNDSynapsedc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
InstitutionInstitut für Anatomie und Zellbiologieuulm.affiliationSpecific
InstitutionUKU. Klinik für Innere Medizin Iuulm.affiliationSpecific
InstitutionUKU. Klinik für Neurologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withDeutsches Zentrum für Neurodegenerative Erkrankungenuulm.cooperation
In cooperation withUniversité de Parisuulm.cooperation
In cooperation withImagine Institute des maladies génétiquesuulm.cooperation
DOI of original publication10.15252/emmm.202013131dc.relation1.doi
Source - Title of sourceEMBO Molecular Medicinesource.title
Source - Place of publicationWiley Open Accesssource.publisher
Source - Volume13source.volume
Source - Issue7source.issue
Source - Year2021source.year
Source - Article numbere13131source.articleNumber
Source - ISSN1757-4684source.identifier.issn
Source - eISSN1757-4676source.identifier.eissn
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE168831dc.relation.isSupplementedBy
Is Supplemented Byhttp://www.ebi.ac.uk/pride/archive/projects/PXD020316dc.relation.isSupplementedBy
Is Supplemented Byhttps://www.embopress.org/action/downloadSupplement?doi=10.15252%2Femmm.202013131&file=emmm202013131-sup-0001-Appendix.pdfdc.relation.isSupplementedBy
Is Supplemented Byhttps://www.embopress.org/action/downloadSupplement?doi=10.15252%2Femmm.202013131&file=emmm202013131-sup-0002-EVFigs.pdfdc.relation.isSupplementedBy
Is Supplemented Byhttps://www.embopress.org/action/downloadSupplement?doi=10.15252%2Femmm.202013131&file=emmm202013131-sup-0003-SDataEV.zipdc.relation.isSupplementedBy
DFG project uulmSFB 1149 / Gefahrenantwort, Störfaktoren und regeneratives Potential nach akutem Trauma / DFG / 251293561uulm.projectDFG
DFG project uulmGRK 1789 / CEMMA / Zelluläre und molekulare Mechanismen der Alterung / DFG / 194266605uulm.projectDFG


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