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AuthorLadel, Simonedc.contributor.author
AuthorFlamm, Johannesdc.contributor.author
AuthorZadeh, Arghavan Soleimanidc.contributor.author
AuthorFilzwieser, Dorotheadc.contributor.author
AuthorWalter, Julia-Christinadc.contributor.author
AuthorSchlossbauer, Patrickdc.contributor.author
AuthorKinscherf, Ralfdc.contributor.author
AuthorLischka, Katharinadc.contributor.author
AuthorLuksch, Haralddc.contributor.author
AuthorSchindowski, Katharinadc.contributor.author
Date of accession2021-11-12T11:53:55Zdc.date.accessioned
Available in OPARU since2021-11-12T11:53:55Zdc.date.available
Date of first publication2018-07-26dc.date.issued
AbstractBackground: The use of therapeutic antibodies for the treatment of neurological diseases is of increasing interest. Nose-to-brain drug delivery is one strategy to bypass the blood brain barrier. The neonatal Fc receptor (FcRn) plays an important role in transepithelial transcytosis of immunoglobulin G (IgG). Recently, the presence of the FcRn was observed in nasal respiratory mucosa. The aim of the present study was to determine the presence of functional FcRn in olfactory mucosa and to evaluate its role in drug delivery. Methods: Immunoreactivity and messenger RNA (mRNA) expression of FcRn was determined in ex vivo porcine olfactory mucosa. Uptake of IgG was performed in a side-by-side cell and analysed by immunofluorescence. Results: FcRn was found in epithelial and basal cells of the olfactory epithelium as well as in glands, cavernous bodies and blood vessels. Allogenic porcine IgGs were found time-dependently in the lamina propria and along axonal bundles, while only small amounts of xenogenic human IgGs were detected. Interestingly, lymphoid follicles were spared from allogenic IgGs. Conclusion: Fc-mediated transport of IgG across the nasal epithelial barrier may have significant potential for intranasal delivery, but the relevance of immune interaction in lymphoid follicles must be clarified to avoid immunogenicity.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordOlfactory epitheliumdc.subject
KeywordRespiratory epitheliumdc.subject
KeywordNALTdc.subject
KeywordLymphoid folliclesdc.subject
KeywordNeuronal bundlesdc.subject
KeywordNose to braindc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHRespiratory mucosadc.subject.mesh
MeSHOlfactory mucosadc.subject.mesh
MeSHNasal mucosadc.subject.mesh
MeSHAntibodies, Monoclonaldc.subject.mesh
MeSHReceptors, Fcdc.subject.mesh
MeSHCell membrane permeabilitydc.subject.mesh
MeSHImmunoglobulin Gdc.subject.mesh
MeSHDrug developmentdc.subject.mesh
TitleAllogenic Fc domain-facilitated uptake of IgG in nasal lamina propria: friend or foe for intranasal CNS delivery?dc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2020-01-28T13:27:05Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-39713dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-39789-0dc.identifier.urn
GNDBronchialschleimhautdc.subject.gnd
GNDEpitheldc.subject.gnd
GNDMonoklonaler Antikörperdc.subject.gnd
GNDFC-Rezeptordc.subject.gnd
GNDPermeationdc.subject.gnd
GNDImmunglobulin Gdc.subject.gnd
GNDArzneimittelentwicklungdc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInternational Graduate School in Molecular Medicine Ulm (IGradU)uulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withHochschule Biberachuulm.cooperation
In cooperation withPhilipps-Universität Marburguulm.cooperation
In cooperation withTechnische Universität Münchenuulm.cooperation
DOI of original publication10.3390/pharmaceutics10030107dc.relation1.doi
Source - Title of sourcePharmaceuticssource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume10source.volume
Source - Issue3source.issue
Source - Year2018source.year
Source - Article number107source.articleNumber
Source - eISSN1999-4923source.identifier.eissn
EU project uulmN2B-patch / Nose-to-Brain-patch / EC / H2020 / 721098uulm.projectEU
CommunityZentrale Einrichtungenuulm.community
CommunityFakultät für Naturwissenschaftenuulm.community
CommunityMedizinische Fakultätuulm.community
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.mdpi.com/1999-4923/10/3/107/s1dc.relation.isSupplementedBy


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