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AuthorSchrage, Benediktdc.contributor.author
AuthorGeelhoed, Bastiaandc.contributor.author
AuthorNiiranen, Teemudc.contributor.author
AuthorGianfagna, Francescodc.contributor.author
AuthorVishram‐Nielsen, Julie K. K.dc.contributor.author
AuthorCostanzo, Simonadc.contributor.author
AuthorSöderberg, Stefandc.contributor.author
AuthorOjeda-Echevarria, Franciscodc.contributor.author
AuthorVartiainen, Erkkidc.contributor.author
AuthorDonati, Maria Benedettadc.contributor.author
AuthorMagnussen, Christinadc.contributor.author
AuthorDi Castelnuovo, Augustodc.contributor.author
AuthorCamen, Stephandc.contributor.author
AuthorKontto, Jukkadc.contributor.author
AuthorKoenig, Wolfgangdc.contributor.author
AuthorBlankenberg, Stefandc.contributor.author
Authorde Gaetano, Giovannidc.contributor.author
AuthorLinneberg, Allandc.contributor.author
AuthorJørgensen, Torbendc.contributor.author
AuthorZeller, Tanjadc.contributor.author
AuthorKuulasmaa, Karidc.contributor.author
AuthorTunstall‐Pedoe, Hughdc.contributor.author
AuthorHughes, Mariadc.contributor.author
AuthorIacoviello, Liciadc.contributor.author
AuthorSalomaa, Veikkodc.contributor.author
AuthorSchnabel, Renate B.dc.contributor.author
Date of accession2021-11-09T12:36:00Zdc.date.accessioned
Available in OPARU since2021-11-09T12:36:00Zdc.date.available
Date of first publication2020-04-30dc.date.issued
AbstractBackground Differences in risk factors for atrial fibrillation (AF) and heart failure (HF) are incompletely understood. Aim of this study was to understand whether risk factors and biomarkers show different associations with incident AF and HF and to investigate predictors of subsequent onset and mortality. Methods and Results In N=58 693 individuals free of AF/HF from 5 population‐based European cohorts, Cox regressions were used to find predictors for AF, HF, subsequent onset, and mortality. Differences between associations were estimated using bootstrapping. Median follow‐up time was 13.8 years, with a mortality of 15.7%. AF and HF occurred in 5.0% and 5.4% of the participants, respectively, with 1.8% showing subsequent onset. Age, male sex, myocardial infarction, body mass index, and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) showed similar associations with both diseases. Antihypertensive medication and smoking were stronger predictors of HF than AF. Cholesterol, diabetes mellitus, and hsCRP (high‐sensitivity C‐reactive protein) were associated with HF, but not with AF. No variable was exclusively associated with AF. Population‐attributable risks were higher for HF (75.6%) than for AF (30.9%). Age, male sex, body mass index, diabetes mellitus, and NT‐proBNP were associated with subsequent onset, which was associated with the highest all‐cause mortality risk. Conclusions Common risk factors and biomarkers showed different associations with AF and HF, and explained a higher proportion of HF than AF risk. As the subsequent onset of both diseases was strongly associated with mortality, prevention needs to be rigorously addressed and remains challenging, as conventional risk factors explained only 31% of AF risk.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY-NC-ND 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by-nc-nd/4.0/dc.rights.uri
KeywordPopulationdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAtrial fibrillationdc.subject.mesh
MeSHHeart failuredc.subject.mesh
MeSHBiomarkersdc.subject.mesh
MeSHHeart disease risk factorsdc.subject.mesh
TitleComparison of cardiovascular risk factors in European population cohorts for predicting atrial fibrillation and heart failure, their subsequent onset, and deathdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2020-12-09T19:30:58Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-39678dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-39754-1dc.identifier.urn
GNDVorhofflimmerndc.subject.gnd
GNDHerzinsuffizienzdc.subject.gnd
GNDBiomarkerdc.subject.gnd
GNDRisikofaktordc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withUniversity of Turku, Finlanduulm.cooperation
In cooperation withNational Institute for Health and Welfare Helsinki, Finlanduulm.cooperation
In cooperation withUniversity of Insubria Varese, Italyuulm.cooperation
In cooperation withBispebjerg and Frederiksberg Hospital Copenhagen, Denmarkuulm.cooperation
In cooperation withUmeå University Hospital, Swedenuulm.cooperation
In cooperation withDeutsches Zentrum für Herz-Kreislauf-Forschunguulm.cooperation
In cooperation withMediterranea Cardiocentro Napoli, Italyuulm.cooperation
In cooperation withTechnische Universität Münchenuulm.cooperation
In cooperation withUniversitäres Herz und Gefäßzentrum UKE Hamburg GmbHuulm.cooperation
In cooperation withUniversity of Copenhagen, Denmarkuulm.cooperation
In cooperation withUniversity of Dundee, United Kingdomuulm.cooperation
In cooperation withQueen′s University Belfast, Northern Irelanduulm.cooperation
In cooperation withIRCCS Neuromed Pozzilli (IS) Italyuulm.cooperation
DOI of original publication10.1161/JAHA.119.015218dc.relation1.doi
Source - Title of sourceJournal of the American Heart Associationsource.title
Source - Place of publicationWiley Open Accesssource.publisher
Source - Volume9source.volume
Source - Issue9source.issue
Source - Year2020source.year
Source - Article numbere015218source.articleNumber
Source - eISSN2047-9980source.identifier.eissn
EU project uulmBIOMARCARE / Biomarker for Cardiovascular Risk Assessment in Europe / EC / FP7 / 278913uulm.projectEU
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.ahajournals.org/action/downloadSupplement?doi=10.1161%2FJAHA.119.015218&file=jah35038-sup-0001-supinfo.pdfdc.relation.isSupplementedBy


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