Deep brain stimulation and behavioural changes : is comedication the most important factor?
Pinkhardt, Elmar H.
Ludolph, Albert C.
Neurodegenerative Diseases ; 9 (2012), 1. - S. 18-24. - ISSN 1660-2854. - eISSN 1660-2862
Link to original publicationhttps://dx.doi.org/10.1159/000328817
InstitutionsUKU. Klinik für Neurologie
External cooperationsEberhard Karls Universität Tübingen
Document versionpublished version (publisher's PDF)
Background: Adverse effects of dopaminergic medication (DA; levodopa and dopamine agonists) on impulsive behaviour and decision-making in patients with Parkinson’s disease (PD) have been repeatedly reported. Deep brain stimulation (DBS) is increasingly used for the treatment of parkinsonian motor symptoms, but the excellent efficacy of DBS contrasts with a growing number of reports that the treatment may result in behavioural complications. Aims: We investigated impulsive behaviour under different therapeutic treatments. Methods: Fifteen patients with PD with DBS (PD-DBS) were assessed with electrical stimulation switched on and off, respectively. Data were compared with those of 15 patients with PD without DBS implantation under DA medication (PD-DA), matched for age and disease duration. Impulsive behaviour (gambling performance) was measured together with neuropsychological assessments regarding depression, current mood and cognitive performance. Results: PD-DA patients performed worse in the gambling task than DBS patients with electrical stimulation turned off. A significant interaction of performance and medication was observed. When DBS was turned on, the differences in performance were less pronounced. Conclusion: For gambling performance, the medication dose mainly explains differences in impulsive behaviour. Although DBS had a minor negative effect on impulsive behaviour, the positive effect of a reduced DA dosis after DBS might reduce impulse control abnormalities. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Subject headings[GND]: Parkinson-Krankheit | Hirnstimulation
[MeSH]: Parkinson disease | Deep brain stimulation | Electric stimulation therapy
[Free subject headings]: Parkinson’s disease | Dopamine dysregulation syndrome | Executive function | Gambling
[DDC subject group]: DDC 610 / Medicine & health
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-39323
Lulé, Dorothée et al. (2021): Deep brain stimulation and behavioural changes : is comedication the most important factor? Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-39323
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