Boolean networks for modeling and analysis of gene regulation
Bericht
Autoren
Zhou, Dao
Müssel, Christoph
Lausser, Ludwig
Hopfensitz, Martin
Kühl, Michael
Fakultäten
Fakultät für Ingenieurwissenschaften und InformatikUlmer Schriftenreihe
Ulmer Informatik-Berichte
Zusammenfassung
Gene-regulatory networks control the expression of genes and therefore the phenotype of cells. Modeling and simulation of such networks can provide deep insights into the functioning of cells. Boolean networks are a commonly used technique to model gene-regulatory networks. We introduce methods to construct Boolean networks from literature knowledge and to analyze their dynamics. In particular, methods to identify and analyze attractors are presented. In simulations on three biological networks, we analyze the robustness of attractors. These evaluations confirm the biological relevance of previously identified attractors.
Erstellung / Fertigstellung
2009
Normierte Schlagwörter
Bioinformatik [GND]Boolesches Netz [GND]
Molekularbiologie [GND]
Genetic regulation [LCSH]
DDC-Sachgruppe
DDC 004 / Data processing & computer scienceMetadata
Zur LanganzeigeZitiervorlage
Zhou, Dao et al. (2011): Boolean networks for modeling and analysis of gene regulation. Open Access Repositorium der Universität Ulm. http://dx.doi.org/10.18725/OPARU-3907