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AuthorVon Streitberg, Axeldc.contributor.author
AuthorJäkel, Sarahdc.contributor.author
AuthorEugenin von Bernhardi, Jaimedc.contributor.author
AuthorStraube, Christophdc.contributor.author
AuthorBuggenthin, Felixdc.contributor.author
AuthorMarr, Carstendc.contributor.author
AuthorDimou, Ledadc.contributor.author
Date of accession2021-10-21T14:07:25Zdc.date.accessioned
Available in OPARU since2021-10-21T14:07:25Zdc.date.available
Date of first publication2021-04-27dc.date.issued
AbstractIn the adult brain, NG2-glia represent a cell population that responds to injury. To further investigate if, how and why NG2-glia are recruited to the injury site, we analyzed in detail the long-term reaction of NG2-glia after a lesion by time-lapse two-photon in vivo microscopy. Live imaging over several weeks of GFP-labeled NG2-glia in the stab wounded cerebral cortex revealed their fast and heterogeneous reaction, including proliferation, migration, polarization, hypertrophy, or a mixed response, while a small subset of cells remained unresponsive. At the peak of the reaction, 2–4 days after the injury, NG2-glia accumulated around and within the lesion core, overcoming the homeostatic control of their density, which normalized back to physiological conditions only 4 weeks after the insult. Genetic ablation of proliferating NG2-glia demonstrated that this accumulation contributed beneficially to wound closure. Thus, NG2-glia show a fast response to traumatic brain injury (TBI) and participate in tissue repair.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordProliferationdc.subject
KeywordMigrationdc.subject
KeywordPolarizationdc.subject
KeywordStab wound injurydc.subject
KeywordIn vivo two-photon imagingdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHBrain injuriesdc.subject.mesh
MeSHNeurogliadc.subject.mesh
MeSHRegenerationdc.subject.mesh
TitleNG2-Glia transiently overcome their homeostatic network and contribute to wound closure after brain injurydc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2021-05-17T16:43:16Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-39256dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-39332-4dc.identifier.urn
GNDSchädel-Hirn-Traumadc.subject.gnd
GNDGliazelledc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Klinik für Neurologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withLudwig-Maximilians-Universität Münchenuulm.cooperation
In cooperation withHelmholtz Zentrum München : Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)uulm.cooperation
DOI of original publication10.3389/fcell.2021.662056dc.relation1.doi
Source - Title of sourceFrontiers in Cell and Developmental Biologysource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume9source.volume
Source - Year2021source.year
Source - Article number662056.source.articleNumber
Source - eISSN2296-634Xsource.identifier.eissn
FundingBMBFuulm.funding
FundingNEURONuulm.funding
Open AccessDOAJ Gold, Green Publisheduulm.OA
WoS000651154900001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.frontiersin.org/articles/10.3389/fcell.2021.662056/full#supplementary-materialdc.relation.isSupplementedBy
DFG project uulmSFB 1149 / Gefahrenantwort, Störfaktoren und regeneratives Potential nach akutem Trauma / DFG / SFB / 251293561uulm.projectDFG


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