Levothyroxine treatment of euthyroid children with autoimmune hashimoto thyroiditis: results of a multicenter, randomized, controlled trial
Dörr, Helmuth G.
Hormone Research in Paediatrics ; 84 (2015), 4. - S. 266-274. - ISSN 1663-2818. - eISSN 1663-2826
Link to original publicationhttps://dx.doi.org/10.1159/000437140
InstitutionsUKU. Klinik für Kinder- und Jugendmedizin
Document versionpublished version (publisher's PDF)
Background: Levothyroxine (L-T4) treatment of euthyroid children with Hashimoto thyroiditis (HT) is a controversial issue. Patients and Methods: We conducted a prospective, randomized, controlled clinical trial. Out of 79 identified euthyroid patients, 59 started the study; 25 patients (21 female, 4 male; age: 11.8 ± 2.3 years) received L-T4 at a mean dose of 1.6 µg/kg (SD, 0.8) daily, and 34 (27 female, 7 male; age: 12.6 ± 1.2 years) were not treated. Patients developing subclinical hypothyroidism during follow-up (n = 13) were treated with L-T4 and removed from the observation group. As the main outcome measures, thyroid gland volume (determined by ultrasound) as well as serum levels of TSH, free T4, and antibodies against thyroid peroxidase and thyroglobulin were assessed every 6 months for 36 months. Results: At the start, the mean thyroid volume (standard deviation score, SDS) was 2.5 in the treatment group and 1.6 in the observation group. There was a constant decline in mean thyroid volume (SDS) from 2.13 (month 12) to 1.12 (month 30) in the treated group, with a delta thyroid volume of -1.01 SDS. In the observation group, the mean delta thyroid volume increased to +0.27 SDS. The change of the delta thyroid volume was statistically significantly different between both groups during the 12- and 30-month time points (p < 0.05). L-T4 had no effect on thyroid function and serum thyroid antibodies. Conclusions: L-T4 treatment can decrease the thyroid volume in euthyroid children with HT, but the effect is limited to a definite time period. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Subject headings[GND]: Hashimoto-Thyreoiditis | Kind | Thyroxin <L->
[MeSH]: Hashimoto disease | Child | Thyroxine; Therapeutic use
[Free subject headings]: Levothyroxine treatment | Euthyroid children | Hashimoto thyroiditis
[DDC subject group]: DDC 610 / Medicine & health
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-39184