Hyperthyroidism in 276 children and adolescents with type 1 diabetes from Germany and Austria

peer-reviewed
Erstveröffentlichung
2015-07-21Authors
Dost, Axel
Rohrer, Tilman
Fröhlich-Reiterer, Elke
Bollow, Esther
Karges, Beate Maria
Wissenschaftlicher Artikel
Published in
Hormone Research in Paediatrics ; 84 (2015), 3. - S. 190-198. - ISSN 1663-2818. - eISSN 1663-2826
Link to original publication
https://dx.doi.org/10.1159/000436964Faculties
Medizinische FakultätInstitutions
Institut für Epidemiologie und Medizinische BiometrieExternal cooperations
Medizinische Universität Graz. Universitätsklinik für Dermatologie und VenerologieUniversitätsklinikum Jena
Universitätsklinikum des Saarlandes
RWTH Aachen
Klinikum Konstanz
Document version
published version (publisher's PDF)Abstract
Background/Aims: Little is known about the incidence and clinical consequences of hyperthyroidism in pediatric patients with type 1 diabetes mellitus (T1DM). Methods: We analyzed the DPV database (Diabetes Prospective Follow-Up Registry) to investigate the rate of hyperthyroidism in pediatric T1DM patients, its impact on metabolic control, and potential associations with organ-specific autoantibodies. Results: Hyperthyroidism was found in 276/60,456 patients (0.46%) and was associated with younger age, shorter diabetes duration, female sex, and reduced body mass index. Diabetic ketoacidosis (DKA) and hypoglycemia were more frequent in T1DM with comorbid hyperthyroidism, while long-term metabolic control (HbA1c) was similar in both groups. Absolute blood pressure and arterial hypertension rate were elevated in the hyperthyroid patients. Rates of microalbuminuria and diabetic retinopathy were not different. Thyroid-specific antibodies (thyroid peroxidase, thyroglobulin, thyroid receptor) were associated with hyperthyroidism. Thyroid volume and rates of cysts and nodules were higher, and echogenicity was decreased. Conclusion: Prevalence of hyperthyroidism is low in diabetic children with T1DM but increased compared to children <18 years without diabetes. Hyperthyroidism is primarily associated with acute diabetes complications (DKA and hypoglycemia) and affects blood pressure regulation. Long-term metabolic control or insulin requirement were not different. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Subject headings
[GND]: Hyperthyreose | Acetonämie | Basedow-Krankheit | Kind | Jugend[MeSH]: Hyperthyroidism | Child | Adolescent | Diabetes mellitus, Type 1 | Diabetic ketoacidosis | Graves disease
[Free subject headings]: Pediatric type 1 diabetes mellitus | DPV Initiative | Metabolic control | Microvascular disease | AUTOIMMUNE HYPERTHYROIDISM | YOUNG-ADULTS | PREVALENCE | MULTICENTER | FREQUENCY
[DDC subject group]: DDC 610 / Medicine & health
Rights notice
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-39161
Dost, Axel et al. (2021): Hyperthyroidism in 276 children and adolescents with type 1 diabetes from Germany and Austria. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-39161
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