Frontal corpus callosum alterations in progressive supranuclear palsy but not in Parkinson's disease
Roßkopf, Johannes C.
Ludolph, Albert C.
Pinkhardt, Elmar Hans
Neurodegenerative Diseases ; 14 (2014), 4. - S. 184-193. - ISSN 1660-2854. - eISSN 1660-2862
Link to original publicationhttps://dx.doi.org/10.1159/000367693
InstitutionsUKU. Klinik für Neurologie
External cooperationsSchweizerische Epilepsie-Stiftung
Document versionpublished version (publisher's PDF)
Background: Frontal lobe involvement is considered a clinical and magnetic resonance imaging (MRI) feature in later stages of progressive supranuclear palsy (PSP). Objective: Diffusion tensor imaging (DTI) was used to investigate the integrity of frontal pathways in PSP and Parkinson's disease (PD) patients. Methods: DTI and 3-D MRI were performed in 15 PSP patients (parkinsonism subtype: n = 8; Richardson subtype: n = 7), 15 PD patients, and 18 matched controls. DTI analysis was performed in order to identify differences along frontal white matter structures including the corpus callosum (CC) and was complemented by atlas-based volumetry and planimetry. Results: Significantly reduced regional fractional anisotropy was observed for PSP patients versus controls and PSP versus PD patients, respectively, in frontal areas including the area II of the CC and bilaterally in the callosal radiation. The DTI findings correlated with frontal lobe volumes. These differences were not observed between PD patients and controls. Conclusion: DTI identified a PSP-associated microstructural alteration pattern in the frontal lobes and in the CC area II including the corresponding bilateral callosal radiation tracts that could not be identified in both control samples, supporting the prominent PSP-associated frontal involvement as a potential neuroimaging marker. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Is supplemented byhttps://karger.figshare.com/articles/dataset/Supplementary_Material_for_Frontal_Corpus_Callosum_Alterations_in_Progressive_Supranuclear_Palsy_but_Not_in_Parkinson_s_Disease/5127028
Subject headings[GND]: Parkinson-Krankheit | Diffusionsgewichtete Magnetresonanztomografie | Anisotropie
[MeSH]: Parkinson disease | Diffusion tensor imaging | Magnetic resonance imaging | Anisotropy
[Free subject headings]: Fractional anisotropy | Parkinsonian syndromes
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-39147