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AuthorMüller, Hans-Peterdc.contributor.author
AuthorKassubek, Jan Rainerdc.contributor.author
Date of accession2021-10-19T13:08:16Zdc.date.accessioned
Available in OPARU since2021-10-19T13:08:16Zdc.date.available
Date of first publication2018-09-26dc.date.issued
AbstractNeuropathological studies revealed the propagation of amyotrophic lateral sclerosis (ALS) in a sequence of four separate disease-related regional patterns. Diffusion tensor imaging (DTI)-based analysis was established for the individual mapping of sequential disease spreading in ALS as the in vivo transfer to neuroimaging. The aim of this review is to summarize cross-sectional and longitudinal results of these technical approaches in ALS as an in vivo tool to image ALS propagation stages. This concept was also applied to restricted phenotypes of ALS, e.g., lower motor neuron disease (LMND) or primary lateral sclerosis (PLS). In summary, the regional disease patterns in the course of ALS have been successfully mapped by DTI in vivo both cross-sectionally and longitudinally so that this technique might have the potential as a read-out in clinical trials.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordfractional anisotropydc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAmyotrophic lateral sclerosisdc.subject.mesh
MeSHMotor neuron diseasedc.subject.mesh
MeSHDiffusion tensor imagingdc.subject.mesh
MeSHAnisotropydc.subject.mesh
MeSHMagnetic resonance imagingdc.subject.mesh
TitleMRI-based mapping of cerebral propagation in amyotrophic lateral sclerosisdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2019-12-19T17:57:24Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-39104dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-39180-0dc.identifier.urn
GNDMyatrophische Lateralsklerosedc.subject.gnd
GNDDiffusionsgewichtete Magnetresonanztomografiedc.subject.gnd
GNDAnisotropiedc.subject.gnd
InstitutionUKU. Klinik für Neurologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeCollectionuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3389/fnins.2018.00655dc.relation1.doi
Source - Title of sourceFrontiers in Neurosciencesource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume12source.volume
Source - Year2018source.year
Source - Article number655source.articleNumber
Source - ISSN1662-4548source.identifier.issn
Source - eISSN1662-453Xsource.identifier.eissn
FundingDeutsche Forschungsgemeinschaft (DFG) [LU 336/15-1]uulm.funding
FundingMND-NET / BMBF [01GM1103A]uulm.funding
CommunityUniversitätsklinikum Ulmuulm.community
Bibliographyuulmuulm.bibliographie


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