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AuthorBielas, Hannesdc.contributor.author
AuthorJud, Andreasdc.contributor.author
AuthorLips, Ulrichdc.contributor.author
AuthorReichenbach, Janinedc.contributor.author
AuthorWieser, Irisdc.contributor.author
AuthorLandolt, Markusdc.contributor.author
Date of accession2021-09-21T13:55:10Zdc.date.accessioned
Available in OPARU since2021-09-21T13:55:10Zdc.date.available
Date of first publication2015-02-18dc.date.issued
AbstractObjective: Adverse childhood experiences, such as maltreatment, and affective disorders are associated with a proinflammatory state and/or variably compromised counts in lymphocyte subsets in adults. Animal models of social stress indicate that recent thymic emigrant cells (RTE), which maintain the T-cell compartment, are affected. Methods: In this study, we examined the association between lymphocyte subsets, and depression and posttraumatic stress disorder (PTSD) among 16 maltreated children (aged 6-17 years) 1-3 years after the intervention by the Child Protection Team and among 14 healthy age-matched controls. The participants completed psychological assessment and had blood drawn for fluorescent-activated cell sorting analysis. Results: Among maltreated children and adolescents, depression was associated with lower counts of RTEs and T-helper cells after controlling for age. We found additional trends and large effect sizes with regard to the percentages of these cells, as well as for related lymphocyte subsets. Similar effects were found for PTSD, i.e. lower counts of naïve T cells, which was also supported by a trend for their percentage. Compared to controls, maltreated participants with a clinical level of depression had decreased percentages of RTEs, with a similar trend for PTSD. Conclusion: Limited by the nature of a pilot study and the small sample size, these preliminary findings of a compromised T-cell compartment related to psychiatric symptoms in maltreated children and adolescents need to be further studied; particularly the role of RTEs needs further evaluation. © In Copyright http://rightsstatements.org/vocab/InC/1.0/ © In Copyright http://rightsstatements.org/vocab/InC/1.0/dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseIn Copyrightdc.rights
Link to license texthttp://rightsstatements.org/vocab/InC/1.0/dc.rights.uri
KeywordChild maltreatmentdc.subject
KeywordDepressiondc.subject
KeywordPosttraumatic stress disorderdc.subject
KeywordRecent thymic emigrant cellsdc.subject
KeywordT cellsdc.subject
KeywordCHILDHOOD MALTREATMENTdc.subject
KeywordIMMUNE FUNCTIONdc.subject
KeywordSOCIAL STRESSdc.subject
KeywordADOLESCENTSdc.subject
KeywordINVENTORYdc.subject
KeywordADULTSdc.subject
KeywordEXPERIENCESdc.subject
KeywordMATURATIONdc.subject
KeywordHISTORYdc.subject
KeywordNEGLECTdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAdverse childhood experiencesdc.subject.mesh
MeSHStress disorders, Post-traumaticdc.subject.mesh
MeSHChild abusedc.subject.mesh
MeSHDepressiondc.subject.mesh
MeSHT-Lymphocytesdc.subject.mesh
TitlePreliminary evidence for a compromised T-Cell compartment in maltreated children with depression and posttraumatic stress disorderdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2020-01-28T13:26:12Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-38852dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-38928-2dc.identifier.urn
GNDKindesvernachlässigungdc.subject.gnd
GNDKindesmisshandlungdc.subject.gnd
GNDPosttraumatisches Stresssyndromdc.subject.gnd
GNDT-Lymphozytdc.subject.gnd
InstitutionUKU. Klinik für Kinder- und Jugendpsychiatrie/Psychotherapieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withKinderspital Zürich - Eleonorenstiftunguulm.cooperation
In cooperation withUniversität Zürichuulm.cooperation
DOI of original publication10.1159/000369349dc.relation1.doi
Source - Title of sourceNeuroimmunomodulationsource.title
Source - Place of publicationKarger Publisherssource.publisher
Source - Volume22source.volume
Source - Issue5source.issue
Source - Year2015source.year
Source - From page303source.fromPage
Source - To page310source.toPage
Source - ISSN1021-7401source.identifier.issn
Source - eISSN1423-0216source.identifier.eissn
Funding‘Perspectives' foundation of Swiss Lifeuulm.funding
FundingOlga Mayenfisch Stiftunguulm.funding
FundingGebert Rüf Stiftunguulm.funding
PubMed25721746uulm.identifier.pubmed
Rights noticeDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.dc.rights.other
Rights noticeThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.dc.rights.other
Bibliographyuulmuulm.bibliographie


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