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AuthorQu, Yangyangdc.contributor.author
Date of accession2021-09-13T13:37:48Zdc.date.accessioned
Available in OPARU since2021-09-13T13:37:48Zdc.date.available
Year of creation2019dc.date.created
Date of first publication2021-09-13dc.date.issued
AbstractBackground: Cardiovascular magnetic resonance based tissue tracking (CMR-TT) was reported to provide detailed insight into bi-ventricular contractile function and deformation with two- and/or three-dimensional (2/3D) algorithms. This study was designed to investigate the feasibility and reproducibility of CMR-TT technique for measuring bi-ventricular segmental, regional and global strains, and establish gender- and age-related reference values of global multi-dimensional peak strains among large healthy population. Methods: We retrospectively recruited 150 healthy volunteers (75 males/females) and divided them into three age groups (G20-40, G41-60 and G61-80). Left ventricular (LV) global mean and peak strains as well as segmental strains in radial, circumferential and longitudinal directions, along with right ventricular free wall (RVFW) longitudinal strains (LS) were derived from post-hoc 2/3D CMR-TT analysis of standard steady-state free precession (SSFP) cine images acquired at 1.5T field strength. Results: CMR-TT modalities enable the tracking of bi-ventricular myocardial tissues and generate strain data. By comparison, 3D CMR-TT was more feasible in measuring segmental deformation since it could generate values at all segments. The amplitudes of LV 3D global peak strain was the smallest among those of 2/3D corresponding global mean or peak strains except in the radial direction, and was highly correlated with 2D global mean strains (correlation coefficient r=0.71-0.90), 2D global peak strains (r=0.75-0.89) and 3D global mean strains (all r=0.99). In healthy cohort, LV 3D global peak values were 44.4±13.0% for radial, -17.0±2.7% for circumferential and -15.4±2.3% for longitudinal strain. The reference value of myocardial RVFW global LS (RVFW-GLS) was -24.9±5.2%. Females showed significantly larger amplitude of strains than males, especially in G61-80 (P<0.05). The subjects in G61-80 showed larger amplitude of strains than the volunteers in younger groups. Meanwhile, females showed more negative RVFW-GLS than males except in the youngest group, and no age-related difference of RVFW-GLS was observed in both gender groups. RVFW regional and segmental LS presented with the same age-related tendency as GLS. The basal and middle-cavity LS were similar between each other and significantly larger than apical LS. The intra- and inter-observer agreement of CMR-TT analysis in evaluating bi-ventricular myocardial global deformation was better than segmental measurement. Conclusion: CMR-TT is a feasible and reproducible technique for assessing bi-ventricular myocardial deformation, especially at the global level. The establishment of specific reference values of bi-ventricular global, regional and segmental systolic strains and the investigation of dimension-, gender- and age-related differences provide a fundamental insight into the features of myocardial contraction and works as an essential step in clinical routine.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordTissue trackingdc.subject
KeywordStraindc.subject
KeywordCardiovasuclar magnetic resonancedc.subject
KeywordCMRdc.subject
KeywordLeft ventricledc.subject
KeywordRight ventricledc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHReference valuesdc.subject.mesh
MeSHMagnetic resonance spectroscopydc.subject.mesh
MeSHHeart ventricles; Diagnostic imagingdc.subject.mesh
MeSHCardiovascular system; Diagnostic imagingdc.subject.mesh
TitleAge- and gender-related reference values of biventricular strains measured by cardiovascular magnetic resonance based tissue trackingdc.title
Resource typeDissertationdc.type
Date of acceptance2021-07-29dcterms.dateAccepted
RefereeRasche, Volkerdc.contributor.referee
RefereeBeer, Meinraddc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-38792dc.identifier.doi
PPN1770840591dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-38868-5dc.identifier.urn
GNDBildgebendes Verfahrendc.subject.gnd
GNDKardiovaskuläres Systemdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Klinik für Innere Medizin IIuulm.affiliationSpecific
InstitutionUKU. Klinik für diagnostische und interventionelle Radiologieuulm.affiliationSpecific
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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