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Auditory memory decay as reflected by a new mismatch negativity score is associated with episodic memory in older adults at risk of dementia

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peer-reviewed

Erstveröffentlichung
2018-02-02
Authors
Laptinskaya, Daria
Thurm, Franka
Küster, Olivia
Fissler, Patrick
Schlee, Winfried
et al.
Wissenschaftlicher Artikel


Published in
Frontiers in Aging Neuroscience ; 10 (2018). - Art.-Nr. 5. - eISSN 1663-4365
Link to original publication
https://dx.doi.org/10.3389/fnagi.2018.00005
Faculties
Fakultät für Ingenieurwissenschaften, Informatik und Psychologie
Institutions
Institut für Psychologie und Pädagogik
UKU. Klinik für Neurologie
External cooperations
Universität Konstanz
Technische Universität Dresden
Universitätsklinikum Regensburg
SAP (Switzerland) AG
Document version
published version (publisher's PDF)
Abstract
The auditory mismatch negativity (MMN) is an event-related potential (ERP) peaking about 100–250 ms after the onset of a deviant tone in a sequence of identical (standard) tones. Depending on the interstimulus interval (ISI) between standard and deviant tones, the MMN is suitable to investigate the pre-attentive auditory discrimination ability (short ISIs, ≤ 2 s) as well as the pre-attentive auditory memory trace (long ISIs, >2 s). However, current results regarding the MMN as an index for mild cognitive impairment (MCI) and dementia are mixed, especially after short ISIs: while the majority of studies report positive associations between the MMN and cognition, others fail to find such relationships. To elucidate these so far inconsistent results, we investigated the validity of the MMN as an index for cognitive impairment exploring the associations between different MMN indices and cognitive performance, more specifically with episodic memory performance which is among the most affected cognitive domains in the course of Alzheimer’s dementia (AD), at baseline and at a 5-year-follow-up. We assessed the amplitude of the MMN for short ISI (stimulus onset asynchrony, SOA = 0.05 s) and for long ISI (3 s) in a neuropsychologically well-characterized cohort of older adults at risk of dementia (subjective memory impairment, amnestic and non-amnestic MCI; n = 57). Furthermore, we created a novel difference score (ΔMMN), defined as the difference between MMNs to short and to long ISI, as a measure to assess the decay of the auditory memory trace, higher values indicating less decay. ΔMMN and MMN amplitude after long ISI, but not the MMN amplitude after short ISI, was associated with episodic memory at baseline (β = 0.38, p = 0.003; β = −0.27, p = 0.047, respectively). ΔMMN, but not the MMN for long ISIs, was positively associated with episodic memory performance at the 5-year-follow-up (β = 0.57, p = 0.013). The results suggest that the MMN after long ISI might be suitable as an indicator for the decline in episodic memory and indicate ΔMMN as a potential biomarker for memory impairment in older adults at risk of dementia.
Publication funding
Open-Access-Förderung durch die Universität Ulm
Subject headings
[GND]: Alzheimerkrankheit | Gedächtnis | Kognition | Leichte kognitive Beeinträchtigung
[MeSH]: Alzheimer disease | Memory | Cognition | Cognitive dysfunction
[Free subject headings]: Mismatch negativity | Auditory memory | Episodic memory | Mild cognitive impairment | Subjective memory impairment | Alzheimer’s disease | Event-related potentials
[DDC subject group]: DDC 610 / Medicine & health
License
CC BY 4.0 International
https://creativecommons.org/licenses/by/4.0/

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-38509

Laptinskaya, Daria et al. (2021): Auditory memory decay as reflected by a new mismatch negativity score is associated with episodic memory in older adults at risk of dementia. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-38509
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