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AuthorKügler, Andreadc.contributor.author
Date of accession2016-03-15T10:43:06Zdc.date.accessioned
Available in OPARU since2016-03-15T10:43:06Zdc.date.available
Year of creation2015dc.date.created
AbstractThe members of the beta2 integrin family of leukocyte adhesion membrane molecules are key regulators of cell-cell and cell-matrix interactions during the inflammatory phase of cutaneous wound healing. Their importance becomes apparent in patients suffering from the leukocyte adhesion deficiency syndrome type 1 (LAD1) with spontaneous skin ulcerations and severe wound healing disturbances due to mutations in the CD18 gene encoding the common beta-chain of the beta2 integrins. CD18-/- mice closely mimic the impaired wound healing phenotype of human LAD1. Previous studies on this mouse model, performed by our laboratory, revealed beta2 integrins and their downstream signalling targets Syk, Vav3 and Rac2 to critically control the phagocytosis of apoptotic neutrophils (PMN) by macrophages with subsequent release of reactive oxygen species (ROS) and active transforming growth factor (TGF)-beta1 at wound sites and thus, normal wound healing. However, the molecular mechanism linking insufficient ROS release from macrophages and reduced activation of TGF-beta1 at wound sites in CD18 deficiency has not been deciphered so far. My PhD thesis addresses the question whether beta2 integrins on macrophages control ROS-dependent TGF-beta1 activation at wound sites and, if so, whether the NADPH oxidase NOX2, as the major source of ROS in phagocytes, is the downstream target of beta2 integrin signalling for the redox-mediated TGF-beta1 activation in wound healing.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (ohne Print-On-Demand)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHMacrophagesdc.subject.mesh
MeSHWound healingdc.subject.mesh
TitleThe role of macrophages in the beta2 Integrin dependent activation of TGF-beta1 in cutaneous wound healingdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-3803dc.identifier.doi
PPN847530191dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-99289dc.identifier.urn
GNDMakrophagedc.subject.gnd
GNDWundheilungdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2016-02-08T08:42:32Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 14.559uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID9928uulm.vtsID
CategoryPublikationenuulm.category


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