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AuthorKhury, Faroukdc.contributor.author
AuthorFuchs, Michaeldc.contributor.author
AuthorMalik, Hassan Awandc.contributor.author
AuthorLeiprecht, Janinadc.contributor.author
AuthorReichel, Heikodc.contributor.author
AuthorFaschingbauer, Martindc.contributor.author
Date of accession2021-06-25T11:46:52Zdc.date.accessioned
Available in OPARU since2021-06-25T11:46:52Zdc.date.available
Date of first publication2021-03-09dc.date.issued
AbstractAims To explore the clinical relevance of joint space width (JSW) narrowing on standardized-flexion (SF) radiographs in the assessment of cartilage degeneration in specific subregions seen on MRI sequences in knee osteoarthritis (OA) with neutral, valgus, and varus alignments, and potential planning of partial knee arthroplasty. Methods We retrospectively reviewed 639 subjects, aged 45 to 79 years, in the Osteoarthritis Initiative (OAI) study, who had symptomatic knees with Kellgren and Lawrence grade 2 to 4. Knees were categorized as neutral, valgus, and varus knees by measuring hip-knee-angles on hip-knee-ankle radiographs. Femorotibial JSW was measured on posteroanterior SF radiographs using a special software. The femorotibial compartment was divided into 16 subregions, and MR-tomographic measurements of cartilage volume, thickness, and subchondral bone area were documented. Linear regression with adjustment for age, sex, body mass index, and Kellgren and Lawrence grade was used. Results We studied 345 neutral, 87 valgus, and 207 varus knees. Radiological JSW narrowing was significantly (p < 0.01) associated with cartilage volume and thickness in medial femorotibial compartment in neutral (r = 0.78, odds ratio (OR) 2.33) and varus knees (r = 0.86, OR 1.92), and in lateral tibial subregions in valgus knees (r = 0.87, OR 3.71). A significant negative correlation was found between JSW narrowing and area of subchondral bone in external lateral tibial subregion in valgus knees (r = −0.65, p < 0.01) and in external medial tibial subregion in varus knees (r = −0.77, p < 0.01). No statistically significant correlation was found in anterior and posterior subregions. Conclusion SF radiographs can be potentially used for initial detection of cartilage degeneration as assessed by MRI in medial and lateral but not in anterior or posterior subregions. Cite this article: Bone Joint Res 2021;10(3):173–187. Keywords: Osteoarthritis cartilage, Joint space narrowing, Partial knee arthroplasty, Osteoarthritis radiography, Cartilage radiographydc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY-NC-ND 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by-nc-nd/4.0/dc.rights.uri
KeywordJoint space narrowingdc.subject
KeywordPartial knee arthroplastydc.subject
KeywordOsteoarthritis radiographydc.subject
KeywordCartilage radiographydc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHOsteoarthritisdc.subject.mesh
MeSHOsteoarthritis; Diagnostic imagingdc.subject.mesh
MeSHCartilagedc.subject.mesh
MeSHArthroplasty, Replacement, Kneedc.subject.mesh
TitleValidation of joint space narrowing on plain radiographs and its relevance to partial knee arthroplastydc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-38062dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-38124-9dc.identifier.urn
GNDOsteoarthritisdc.subject.gnd
GNDKnorpeldc.subject.gnd
GNDKniegelenkprothesedc.subject.gnd
InstitutionRehabilitationskrankenhaus Ulmuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withRambam Health Care Campusuulm.cooperation
DOI of original publication10.1302/2046-3758.103.BJR-2020-0216.R1dc.relation1.doi
Source - Title of sourceBone & Joint Researchsource.title
Source - Place of publicationBritish Editorial Society of Bone and Joint Surgerysource.publisher
Source - Volume10source.volume
Source - Issue3source.issue
Source - Year2021source.year
Source - From page173source.fromPage
Source - To page187source.toPage
Source - eISSN2046-3758source.identifier.eissn
Bibliographyuulmuulm.bibliographie


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