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AuthorSeitz, Andreas Martindc.contributor.author
AuthorOsthaus, Felixdc.contributor.author
AuthorSchwer, Jonasdc.contributor.author
AuthorWarnecke, Danieladc.contributor.author
AuthorFaschingbauer, Martindc.contributor.author
AuthorSgroi, Mircodc.contributor.author
AuthorIgnatius, Anitadc.contributor.author
AuthorDürselen, Lutzdc.contributor.author
Date of accession2021-06-02T09:08:18Zdc.date.accessioned
Available in OPARU since2021-06-02T09:08:18Zdc.date.available
Date of first publication2021-05-06dc.date.issued
AbstractAn exact understanding of the interplay between the articulating tissues of the knee joint in relation to the osteoarthritis (OA)-related degeneration process is of considerable interest. Therefore, the aim of the present study was to characterize the biomechanical properties of mildly and severely degenerated human knee joints, including their menisci and tibial and femoral articular cartilage (AC) surfaces. A spatial biomechanical mapping of the articulating knee joint surfaces of 12 mildly and 12 severely degenerated human cadaveric knee joints was assessed using a multiaxial mechanical testing machine. To do so, indentation stress relaxation tests were combined with thickness and water content measurements at the lateral and medial menisci and the AC of the tibial plateau and femoral condyles to calculate the instantaneous modulus (IM), relaxation modulus, relaxation percentage, maximum applied force during the indentation, and the water content. With progressing joint degeneration, we found an increase in the lateral and the medial meniscal instantaneous moduli (p < 0.02), relaxation moduli (p < 0.01), and maximum applied forces (p < 0.01), while for the underlying tibial AC, the IM (p = 0.01) and maximum applied force (p < 0.01) decreased only at the medial compartment. Degeneration had no influence on the relaxation percentage of the soft tissues. While the water content of the menisci did not change with progressing degeneration, the severely degenerated tibial AC contained more water (p < 0.04) compared to the mildly degenerated tibial cartilage. The results of this study indicate that degeneration-related (bio-)mechanical changes seem likely to be first detectable in the menisci before the articular knee joint cartilage is affected. Should these findings be further reinforced by structural and imaging analyses, the treatment and diagnostic paradigms of OA might be modified, focusing on the early detection of meniscal degeneration and its respective treatment, with the final aim to delay osteoarthritis onset.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordKneedc.subject
KeywordDegenerationdc.subject
KeywordInstantaneous modulusdc.subject
KeywordThicknessdc.subject
KeywordWater contentdc.subject
KeywordEquilibrium modulusdc.subject
KeywordMappingdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHKnee; Pathologydc.subject.mesh
MeSHMeniscusdc.subject.mesh
TitleOsteoarthritis-related degeneration alters the biomechanical properties of human menisci before the articular cartilagedc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-37872dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-37934-8dc.identifier.urn
GNDKniegelenkdc.subject.gnd
GNDDegenerationdc.subject.gnd
InstitutionUKU. Institut für Unfallchirurgische Forschung und Biomechanikuulm.affiliationSpecific
InstitutionRehabilitationskrankenhaus Ulmuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3389/fbioe.2021.659989dc.relation1.doi
Source - Title of sourceFrontiers in Bioengineering and Biotechnologysource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume9source.volume
Source - Year2021source.year
Source - Article number659989source.articleNumber
Source - eISSN2296-4185source.identifier.eissn
FundingDFG [DU 254/10-1]uulm.funding
Open AccessDOAJ Gold, Green Publisheduulm.OA
WoS000652027900001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.659989/full#supplementary-materialdc.relation.isSupplementedBy


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