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AuthorMüller, Maximiliandc.contributor.author
Date of accession2016-03-15T10:42:45Zdc.date.accessioned
Available in OPARU since2016-03-15T10:42:45Zdc.date.available
Year of creation2014dc.date.created
AbstractIntroduction: Haemorrhage is the leading cause of preventable death in military conflicts. Different types of haemostatic dressings have been developed and have been compared in animal studies for their ability to control bleeding. The effects of haemostatic agents in animals may be different from those in humans. It is still unclear what animal species is most similar to humans in terms of the physiology of blood coagulation. In addition, there is a paucity of data comparing the effects of different haemostatic dressings in humans. Material and methods: Rotational thromboelastometry (ROTEM) was used to analyse coagulation in various animal species (pigs, sheep, rabbits, and dogs) and to compare it with human coagulation. In addition, ROTEM was used to examine the efficacy of different haemostatic dressings (QuikClot® Gauze TM, Celox TM Gauze and QuikClot ACS+ TM) in comparison to standard gauze in human blood. Results: All animal species showed differences in coagulation properties when compared to humans. Dogs and sheep were most similar to humans in terms of coagulation. QuikClot® Gauze TM was the most efficacious haemostatic dressing, followed by Celox TM Gauze and standard gauze. QuikClot ACS+ TM was clearly outperformed by all other dressings. Conclusion: Our results suggest that dogs and sheep should be preferred to pigs or rabbits in haemostatic research. Furthermore modern haemostatic dressings such as QuikClot® Gauze TM and Celox TM Gauze should be preferred to previous generations of haemostatic dressings such as QuikClot ACS+ TM. In-vitro studies like rotational thromboelastometry can provide valuable information about the mechanisms of action of haemostatic dressings. A combination of different mechanisms of action may increase the efficacy of haemostatic dressings.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordHämostyptikadc.subject
KeywordRotationsthromboelastometriedc.subject
KeywordROTEM®dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHBlood coagulationdc.subject.mesh
MeSHThrombelastographydc.subject.mesh
TitleEvaluation der Blutgerinnung verschiedener Großtiermodelle und Vergleich des prokoagulatorischen Effektes der Hämostyptika QuikClot® Gauze TM, Celox TM Gauze, QuikClot ACS+ TM und H&H PriMed Compressed Gauze mit der Rotationsthromboelastometriedc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-3720dc.identifier.doi
PPN842310428dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-97902dc.identifier.urn
GNDBlutgerinnungdc.subject.gnd
GNDBlutstillungsmitteldc.subject.gnd
GNDHunddc.subject.gnd
GNDKaninchendc.subject.gnd
GNDMenschdc.subject.gnd
GNDSchafdc.subject.gnd
GNDSchweindc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2015-11-17T11:16:09Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionW: W-H 14.455uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID9790uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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