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AuthorJiang, Dongshengdc.contributor.author
AuthorScharffetter-Kochanek, Karindc.contributor.author
Date of accession2021-04-22T14:10:00Zdc.date.accessioned
Available in OPARU since2021-04-22T14:10:00Zdc.date.available
Date of first publication2020-07-29dc.date.issued
AbstractGranulation tissue formation constitutes a key step during wound healing of the skin and other organs. Granulation tissue concomitantly initiates regenerative M2 macrophages polarization, fibroblast proliferation, myofibroblast differentiation with subsequent contraction of the wound, new vessel formation, and matrix deposition. Impaired granulation tissue formation either leads to delayed wound healing or excessive scar formation, conditions with high morbidity and mortality. Accumulating evidence has demonstrated that mesenchymal stem cell (MSC)-based therapy is a promising strategy to ameliorate defects in granulation tissue formation and to successfully treat non-healing chronic wounds. In this review we give an updated overview of how therapeutically administered MSCs ensure a balanced granulation tissue formation, and furthermore discuss the cellular and molecular mechanisms underlying the adaptive responses of MSCs to cue in their direct neighborhood. Improved understanding of the interplay between the exogenous MSCs and their niche in granulation tissue will foster the development of MSC-based therapies tailored for difficult-to-treat non-healing wounds.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordenvironment sensingdc.subject
Keywordscarringdc.subject
Keywordproliferationdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHMesenchymal stem cellsdc.subject.mesh
MeSHWound healingdc.subject.mesh
MeSHGranulation tissuedc.subject.mesh
MeSHMyofibroblastsdc.subject.mesh
MeSHInflammationdc.subject.mesh
TitleMesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healingdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2020-12-09T19:38:36Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-36778dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-36840-5dc.identifier.urn
GNDMesenchymzelledc.subject.gnd
GNDGranulationsgewebedc.subject.gnd
GNDMyofibroblastdc.subject.gnd
GNDWundheilungdc.subject.gnd
GNDEntzündungdc.subject.gnd
InstitutionUKU. Klinik für Dermatologie und Allergologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeCollectionuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withHelmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)uulm.cooperation
DOI of original publication10.3389/fcell.2020.00697dc.relation1.doi
Source - Title of sourceFrontiers in Cell and Developmental Biologysource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume8source.volume
Source - Year2020source.year
Source - Article number697source.articleNumber
Source - eISSN2296-634Xsource.identifier.eissn
EU project uulmCASCADE / Cultivated Adult Stem Cells as Alternative for Damaged tissue / EC / FP7 / 223236uulm.projectEU
Bibliographyuulmuulm.bibliographie
DFG project uulmSFB 1149 / Gefahrenantwort, Störfaktoren und regeneratives Potential nach akutem Trauma / DFG / 251293561uulm.projectDFG
Project uulmBausteinprogramm der Medizinischen Fakultät / Universität Ulmuulm.projectOther
xmlui.metadata.uulm.OAfundingGefördert vom Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberguulm.OAfunding
xmlui.metadata.uulm.OAfundingOpen-Access-Förderung durch die Medizinische Fakultät der Universität Ulmuulm.OAfunding


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