• English
    • Deutsch
Dokumentanzeige 
  •   OPARU Startseite
  • Medizinische Fakultät
  • Publikationen
  • Dokumentanzeige
  •   OPARU Startseite
  • Medizinische Fakultät
  • Publikationen
  • Dokumentanzeige
  • Deutsch 
    • English
    • Deutsch
  • Einloggen
JavaScript is disabled for your browser. Some features of this site may not work without it.

Funktion und pathophysiologische Bedeutung Granzym B-exprimierender regulatorischer B-Zellen

Thumbnail
Download
vts_9599_14533.pdf (1.823Mb)
89 S.
 
Veröffentlichung
2015-07-15
DOI
10.18725/OPARU-3646

Dissertation

Autoren
Lindner, Stefanie
Fakultäten
Medizinische Fakultät
Lizenz
Standard (ohne Print-On-Demand)
https://oparu.uni-ulm.de/xmlui/license_opod_v1
Zusammenfassung
Human B cells have the ability to express the serine protease granzyme B (GrB) in response to the stimulation with Interleukin 21 (IL-21), a cytokine primarily found in the acute phase of infections. These GrB+ B cells can exhibit regulatory potential. Our experiments show that GrB+ B cells were found in the microenvironment of solid tumors and also have regulatory effects on T cell proliferation. This phenomenon resembles the effect of regulatory T cells (Treg). To verify the regulatory function of GrB+ B cells, we characterized the molecular mechanism of the suppression of T cell proliferation. A direct substrate of Granzym B is the T cell receptor zeta chain, which is essential for the signal transduction in T cells. We could demonstrate that B cells expressing GrB after stimulation with IL-21, degrade the TCR zeta chain of CD4+ T cells. Furthermore these GrB+ B cells also express regulatory molecules like IDO and IL-10. To support our findings in vivo, we screened different pathological tissues such as colorectal-, prostate- or breast carinomas. We were able to show the existence of GrB+ B cells in all screened tissues, which is dependent on the presence of IL-21 in these tumors. We also found IL-10 expressing B cells in the tumor microenvironment. This indicates a regulatory effect of GrB+ B cells in cancer immunity. Our findings could have significant implications on our understanding of the role of B cells in immune regulation and for a broad variety of immune phenomena including auto-, cancer and infectious immunity.
Erstellung / Fertigstellung
2015
Normierte Schlagwörter
Granzyme [GND]
Serinproteinasen [GND]
B-lymphocytes, regulatory [MeSH]
Schlagwörter
Breg cells; Granzym B
DDC-Sachgruppe
DDC 610 / Medicine & health

Metadata
Zur Langanzeige

Zitiervorlage

Lindner, Stefanie (2015): Funktion und pathophysiologische Bedeutung Granzym B-exprimierender regulatorischer B-Zellen. Open Access Repositorium der Universität Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-3646

Weitere Zitierstile



Informationen zu OPARU | Kontakt | Feedback
Impressum | Datenschutzerklärung
 

 

Erweiterte Suche

Stöbern

Gesamter BestandBereiche & SammlungenFakultätenInstitutionenPersonenRessourcentypenUlmer Reihen & ZeitschriftenDDC-SachgruppenFörderinformationenAusgewählte SammlungFakultätenInstitutionenPersonenRessourcentypenUlmer Reihen & ZeitschriftenDDC-SachgruppenFörderinformationen

Mein Benutzerkonto

EinloggenRegistrieren

Statistik

Benutzungsstatistik

Informationen zu OPARU | Kontakt | Feedback
Impressum | Datenschutzerklärung