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AuthorAhmad, Mubashirdc.contributor.author
AuthorHachemi, Yasminedc.contributor.author
AuthorPaxian, Kevindc.contributor.author
AuthorKoenen, Maschadc.contributor.author
AuthorMengele, Florian Julius Martin Maxdc.contributor.author
AuthorTuckermann, Jan Peter Gottfrieddc.contributor.author
Date of accession2021-03-30T07:19:51Zdc.date.accessioned
Available in OPARU since2021-03-30T07:19:51Zdc.date.available
Date of first publication2019-10-17dc.date.issued
AbstractGlucocorticoids (GCs) are known to have a strong impact on the immune system, metabolism, and bone homeostasis. While these functions have been long investigated separately in immunology, metabolism, or bone biology, the understanding of how GCs regulate the cellular cross-talk between innate immune cells, mesenchymal cells, and other stromal cells has been garnering attention rather recently. Here we review the recent findings of GC action in osteoporosis, inflammatory bone diseases (rheumatoid and osteoarthritis), and bone regeneration during fracture healing. We focus on studies of pre-clinical animal models that enable dissecting the role of GC actions in innate immune cells, stromal cells, and bone cells using conditional and function-selective mutant mice of the GC receptor (GR), or mice with impaired GC signaling. Importantly, GCs do not only directly affect cellular functions, but also influence the cross-talk between mesenchymal and immune cells, contributing to both beneficial and adverse effects of GCs. Given the importance of endogenous GCs as stress hormones and the wide prescription of pharmaceutical GCs, an improved understanding of GC action is decisive for tackling inflammatory bone diseases, osteoporosis, and aging.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordGlucocorticoid receptordc.subject
KeywordConditional knockout micedc.subject
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHGlucocorticoidsdc.subject.mesh
MeSHReceptors, Glucocorticoiddc.subject.mesh
MeSHOsteoporosisdc.subject.mesh
MeSHArthritisdc.subject.mesh
MeSHInflammationdc.subject.mesh
MeSHFracture Healingdc.subject.mesh
MeSHMice, Knockoutdc.subject.mesh
TitleA jack of all trades: impact of glucocorticoids on cellular cross-talk in osteoimmunologydc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2019-12-19T17:56:25Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-36424dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-36486-1dc.identifier.urn
GNDGlucocorticosteroidedc.subject.gnd
GNDOsteoporosedc.subject.gnd
GNDArthritisdc.subject.gnd
GNDEntzündungdc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
InstitutionInstitut für Molekulare Endokrinologie der Tiereuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withYale School of Medicineuulm.cooperation
In cooperation withA4 Zentrum für Orthopädie, Unfallchirurgie, Gefäßchirurgie, Neurochirurgie, Physikalische und Rehabil. Medizinuulm.cooperation
DOI of original publication10.3389/fimmu.2019.02460dc.relation1.doi
Source - Title of sourceFrontiers in Immunologysource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume10source.volume
Source - Year2019source.year
Source - Article number2460source.articleNumber
Source - eISSN1664-3224source.identifier.eissn
FundingCollaborative Research Centre 1149 Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma / DFG [251293561 ; C02/InSt 40/492-2 ; Tu220/13-1 ; Tu 220/14-1]uulm.funding
University Bibliographyjauulm.unibibliographie


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CC BY 4.0 International
Except where otherwise noted, this item's license is described as CC BY 4.0 International