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AbstractMyeloid-derived suppressor cells (MDSCs) expand during inflammation and exhibit immunomodulatory functions on innate and adaptive immunity. However, their impact on trauma-induced immune responses, characterized by an early pro-inflammatory phase and dysregulated adaptive immunity involving lymphocyte apoptosis, exhaustion and unresponsiveness is less clear. Therefore, we adoptively transferred in vitro-generated MDSCs shortly before experimental blunt chest trauma (TxT). MDSCs preferentially homed into spleen and liver, but were undetectable in the injured lung, although pro-inflammatory mediators transiently increased in the bronchoalveolar lavage (BAL). Surprisingly, MDSC treatment strongly increased splenocyte numbers, however, without altering the percentage of splenic leukocyte populations. T cells of MDSC-treated TxT mice exhibited an activated phenotype characterized by expression of activation markers and elevated proliferative capacity in vitro, which was not accompanied by up-regulated exhaustion markers or unresponsiveness towards in vitro activation. Most importantly, also T cell expansion after staphylococcal enterotoxin B (SEB) stimulation in vivo was unchanged between MDSC-treated or untreated mice. After MDSC transfer, T cells preferentially exhibited a Th1 phenotype, a prerequisite to circumvent post-traumatic infectious complications. Our findings reveal a totally unexpected immunostimulatory role of adoptively transferred MDSCs in TxT and might offer options to interfere with post-traumatic malfunction of the adaptive immune response.dc.description.abstract
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license text
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
LCSHCell biologydc.subject.lcsh
MeSHMyeloid-derived suppressor cellsdc.subject.mesh
MeSHBronchoalveolar lavagedc.subject.mesh
TitleImmunostimulatory functions of adoptively transferred MDSCs in experimental blunt chest traumadc.title
Resource typeWissenschaftlicher Artikeldc.type
GNDMyeloide Suppressorzelledc.subject.gnd
GNDBroncho-alveoläre Lavagedc.subject.gnd
InstitutionUKU. Klinik für Kinder- und Jugendmedizinuulm.affiliationSpecific
InstitutionUKU. Institut für Klinische und Experimentelle Trauma-Immunologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
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DOI of original publication10.1038/s41598-019-44419-5dc.relation1.doi
Source - Title of sourceScientific Reportssource.title
Source - Place of publicationNature Researchsource.publisher
Source - Volume9source.volume
Source - Year2019source.year
Source - Article number7992source.articleNumber
Source - eISSN2045-2322source.identifier.eissn
FundingDie Rolle von myeloiden Suppressorzellen (MDSCs) nach Trauma-induziertem septischen Lungenschaden (A07) / DFG [251293561]uulm.funding
FundingBIU 2 / Universität Ulmuulm.funding
FundingPromotionsprogramm Experimentelle Medizin / Universitätsklinikum Ulmuulm.funding
University Bibliographyjauulm.unibibliographie

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CC BY 4.0 International
Except where otherwise noted, this item's license is described as CC BY 4.0 International