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AuthorSchmiech, Michaeldc.contributor.author
AuthorLang, Sophia J.dc.contributor.author
AuthorWerner, Katharinadc.contributor.author
AuthorRashan, Luay J.dc.contributor.author
AuthorSyrovets, Tatianadc.contributor.author
AuthorSimmet, Thomasdc.contributor.author
Date of accession2021-03-29T13:45:29Zdc.date.accessioned
Available in OPARU since2021-03-29T13:45:29Zdc.date.available
Date of first publication2019-06-07dc.date.issued
AbstractPentacyclic triterpenic acids from oleogum resins of Boswellia species are of considerable therapeutic interest. Yet, their pharmaceutical development is hampered by uncertainties regarding botanical identification and the complexity of triterpenic acid mixtures. Here, a highly sensitive, selective, and accurate method for the simultaneous quantification of eight boswellic and lupeolic acids by high-performance liquid chromatography with tandem mass spectrometry detection (HPLC-MS/MS) was developed. The method was applied to the comparative analysis of 41 oleogum resins of the species B. sacra, B. dalzielli, B. papyrifera, B. serrata, B. carterii, B. neglecta, B. rivae, B. frereana, and B. occulta. Multivariate statistical analysis of the data revealed di erences in the triterpenic acid composition that could be assigned to distinct Boswellia species and to their geographic growth location. Extracts of the oleogum resins exhibited cytotoxicity against the human, treatment-resistant, metastatic breast cancer cell line MDA-MB-231. Extracts from B. sacra were the most potent ones with an average IC50 of 8.350 0.6 +-g/mL. The oleogum resin of the B. sacra was further fractionated to enrich different groups of substances. The cytotoxic effcacy against the cancer cells correlates positively with the contents of pentacyclic triterpenic acids in Boswellia extracts.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordBoswellia occultadc.subject
KeywordPentacyclic triterpenic aciddc.subject
KeywordBoswellic aciddc.subject
KeywordLupeolic aciddc.subject
KeywordBreast cancerdc.subject
KeywordMDA-MB-231dc.subject
Dewey Decimal GroupDDC 540 / Chemistry & allied sciencesdc.subject.ddc
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHBreast neoplasmsdc.subject.mesh
MeSHBoswelliadc.subject.mesh
MeSHFrankincensedc.subject.mesh
TitleComparative analysis of pentacyclic triterpenic acid compositions in oleogum resins of different Boswellia species and their In vitro cytotoxicity against treatment-resistant human breast cancer cellsdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-36420dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-36482-7dc.identifier.urn
GNDBrustkrebsdc.subject.gnd
GNDWeihrauchstrauchdc.subject.gnd
InstitutionUKU. Institut für Naturheilkunde und Klinische Pharmakologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withDhofar Universityuulm.cooperation
DOI of original publication10.3390/molecules24112153dc.relation1.doi
Source - Title of sourceMoleculessource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume24source.volume
Source - Issue11source.issue
Source - Year2019source.year
Source - Article number2153source.articleNumber
Source - eISSN1420-3049source.identifier.eissn
FundingMinisterium für Wissenschaft, Forschung und Kunst Baden-Württemberguulm.funding
FundingAcademic Center for Complementary and Integrative Medicineuulm.funding
University Bibliographyjauulm.unibibliographie


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CC BY 4.0 International
Except where otherwise noted, this item's license is described as CC BY 4.0 International