• English
    • Deutsch
View Item 
  •   OPARU Home
  • Medizinische Fakultät
  • Publikationen
  • View Item
  •   OPARU Home
  • Medizinische Fakultät
  • Publikationen
  • View Item
  • English 
    • English
    • Deutsch
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Vergleichende Genexpressionsanalyse in viszeralem Fettgewebe von Patienten mit Colorektalen Karzinomen und Adipositas sowie Nachweis der Expression von HMW- Adiponektin im Serum

Thumbnail
Download
vts_9491_14333.pdf (1.301Mb)
87 S.
 
Veröffentlichung
2015-05-21
DOI
10.18725/OPARU-3598
Dissertation


Authors
Wurster, Elena Felicia
Faculties
Medizinische Fakultät
License
Standard (ohne Print-On-Demand)
https://oparu.uni-ulm.de/xmlui/license_opod_v1
Abstract
In the last years, the prevalence of obesity and its concomitant diseases, such as colorectal cancers, have increased dramatically worldwide. The underlying causes thereof are only speculative. In addition to other factors, cancer may be potentiated by underlying inflammation resultant from an imbalance in pro- and anti-inflammatory cytokines and adipocytokines. This dissertation addressed the potential effect of visceral adipose tissue as an endocrine organ, favoring altering adipocytokine levels in obese patients, and promoting colorectal cancer genesis. The study collective under investigation consisted of 38 obese patients and 46 patients with history of colorectal cancer. Gene expression analyses of Chemokine CXC Motif Ligand 5 (CXCL5), Chemokine CC Motif Ligand 15 (CCL15) and Chemokine CC Motif Ligand 20 (CCL20) were performed using visceral adipose tissue from both collectives. Comparative analysis of serum levels of high-molecular-weight adiponectin, and analysis of baseline data was also performed. Differences were detected with respect to baseline data, blood serum expression of high-molecular-weight adiponectin, and routine parameters for monitoring glucose, lipid and liver metabolism, as well as inflammation. In contrast, however, both collectives showed comparable expression for CXCL5, CCL15 and CCL20 in visceral adipose tissue. These findings imply a potential deleterious effect for cytokines in the development of obesity associated Colorectal Cancer genesis.
Date created
2014
Subject Headings
Abdominal fat [MeSH]
Adipokines [MeSH]
Adiponectin [MeSH]
Chemokine CCL 15 [MeSH]
Chemokine CCL 20 [MeSH]
Chemokine CXCL5 [MeSH]
Chemokines, CXC [MeSH]
Colorectal neoplasms [MeSH]
Obesity [MeSH]
Obesity, abdominal [MeSH]
Dewey Decimal Group
DDC 610 / Medicine & health

Metadata
Show full item record

Citation example

Wurster, Elena Felicia (2015): Vergleichende Genexpressionsanalyse in viszeralem Fettgewebe von Patienten mit Colorektalen Karzinomen und Adipositas sowie Nachweis der Expression von HMW- Adiponektin im Serum. Open Access Repositorium der Universität Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-3598

Other citation formats



About OPARU | Contact Us
Impressum | Privacy statement
 

 

Advanced Search

Browse

All of OPARUCommunities & CollectionsFacultiesInstitutionsPersonsResource typesUlm SerialsDewey Decimal ClassesFundingThis CollectionFacultiesInstitutionsPersonsResource typesUlm SerialsDewey Decimal ClassesFunding

My Account

LoginRegister

Statistics

View Usage Statistics

About OPARU | Contact Us
Impressum | Privacy statement