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AuthorBlinder, Tetyanadc.contributor.author
AuthorLewerenz, Jandc.contributor.author
Date of accession2021-03-01T14:49:08Zdc.date.accessioned
Available in OPARU since2021-03-01T14:49:08Zdc.date.available
Date of first publication2019-07-25dc.date.issued
AbstractAutoimmune encephalitides (AIE) comprise a group of inflammatory diseases of the central nervous system (CNS), which can be further characterized by the presence of different antineuronal antibodies. Recently, a clinical approach for diagnostic criteria for the suspected diagnosis of AIE as well as definitive AIE were proposed. These are intended to guide physicians when to order the antineuronal antibody testing and/or facilitate early diagnosis even prior to the availability of the specific disease-confirming test results to facilitate prompt treatment. These diagnostic criteria also include the results of basic cerebrospinal fluid (CSF) analysis. However, the different antibody-defined AIE subtypes might be highly distinct with regard to their immune pathophysiology, e.g., the pre-dominance of specific IgG subclasses, IgG1, or IgG4, or frequency of paraneoplastic compared to idiopathic origin. Thus, it is conceivable that the results of basic CSF analysis might also be very different. However, this has not been explored systematically. Here, we systematically reviewed the literature about the 10 most important AIE subtypes, AIE with antibodies against NMDA, AMPA, glycine, GABAA, and GABAB receptors as well as DPPX, CASPR2, LGI1, IgLON5, or glutamate decarboxylase (GAD), with respect to the reported basic CSF findings comprising CSF leukocyte count, total protein, and the presence of oligoclonal bands (OCB) restricted to the CSF as a sensitive measure for intrathecal IgG synthesis. Our results indicate that these basic CSF findings are profoundly different among the 10 different AIE subtypes. Whereas, AIEs with antibodies against NMDA, GABAB, and AMPA receptors as well as DPPX show rather frequent inflammatory CSF changes, in AIEs with either CASPR2, LGI1, GABAA, or glycine receptor antibodies CSF findings were mostly normal. Two subtypes, AIEs defined by either GAD, or IgLON5 antibodies, did not fit into this general pattern. In AIE with GAD antibodies, positive OCBs in the absence of other changes were typical, while the CSF in IgLON5 antibody-positive AIE was characterized by elevated protein.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordAutoimmune encephalitisdc.subject
KeywordAntineuronal antibodiesdc.subject
KeywordPleocytosisdc.subject
KeywordOligoclonal bandsdc.subject
KeywordNMDAR antibodiesdc.subject
KeywordLGI1 antibodiesdc.subject
KeywordGAD antibodiesdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHEncephalitisdc.subject.mesh
MeSHCerebrospinal fluiddc.subject.mesh
MeSHLeukocytosisdc.subject.mesh
MeSHReceptors, N-Methyl-D-Aspartatedc.subject.mesh
TitleCerebrospinal fluid findings in patients with autoimmune encephalitis—a systematic analysisdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-35521dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-35583-3dc.identifier.urn
GNDEncephalitisdc.subject.gnd
GNDLiquor cerebrospinalisdc.subject.gnd
GNDNMDA-Antagonistdc.subject.gnd
InstitutionUKU. Klinik für Neurologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3389/fneur.2019.00804dc.relation1.doi
Source - Title of sourceFrontiers in Neurologysource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume10source.volume
Source - Year2019source.year
Source - Article number804source.articleNumber
Source - eISSN1664-2295source.identifier.eissn
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.frontiersin.org/articles/10.3389/fneur.2019.00804/full#supplementary-materialdc.relation.isSupplementedBy


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