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AuthorGarcía Reyes, Balbinadc.contributor.author
AuthorKretz, Anna-Lauradc.contributor.author
AuthorRuff, Jan-Philippdc.contributor.author
AuthorKarstedt, Silvia vondc.contributor.author
AuthorHillenbrand, Andreasdc.contributor.author
AuthorKnippschild, Uwedc.contributor.author
AuthorHenne-Bruns, Dorisdc.contributor.author
AuthorLemke, Johannesdc.contributor.author
Date of accession2021-03-01T14:36:17Zdc.date.accessioned
Available in OPARU since2021-03-01T14:36:17Zdc.date.available
Date of first publication2018-10-18dc.date.issued
AbstractThe family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been linked to cancer initiation and progression. Pharmacological CDK inhibition has recently emerged as a novel and promising approach in cancer therapy. This idea is of particular interest to combat pancreatic ductal adenocarcinoma (PDAC), a cancer entity with a dismal prognosis which is owed mainly to PDAC’s resistance to conventional therapies. Here, we review the current knowledge of CDK biology, its role in cancer and the therapeutic potential to target CDKs as a novel treatment strategy for PDAC.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordPancreatic cancerdc.subject
KeywordPancreatic ductal adenocarcinomadc.subject
KeywordCDKdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHPancreatic neoplasmsdc.subject.mesh
MeSHCyclin-dependent kinasesdc.subject.mesh
TitleThe emerging role of cyclin-dependent kinases (CDKs) in pancreatic ductal adenocarcinomadc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-35520dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-35582-7dc.identifier.urn
GNDBauchspeicheldrüsenkrebsdc.subject.gnd
GNDCyclin-abhängige Kinasendc.subject.gnd
InstitutionUKU. Klinik für Allgemein- und Viszeralchirurgieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withUniversitätsklinikum Kölnuulm.cooperation
In cooperation withUniversität zu Kölnuulm.cooperation
DOI of original publication:10.3390/ijms19103219dc.relation1.doi
Source - Title of sourceInternational Journal of Molecular Sciencessource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume19source.volume
Source - Issue10source.issue
Source - Year2018source.year
Source - Article number3219source.articleNumber
Source - ISSN1661-6596source.identifier.issn
Source - eISSN1422-0067source.identifier.eissn
FundingDFG [LE3556/1-1]uulm.funding
FundingMax-Eder-Nachwuchsgruppenprogramm / Deutsche Krebshilfeuulm.funding
WoS000448951000374uulm.identifier.wos
Bibliographyuulmuulm.bibliographie


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