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AuthorKretz, Anna-Lauradc.contributor.author
AuthorTrauzold, Annadc.contributor.author
AuthorHillenbrand, Andreasdc.contributor.author
AuthorKnippschild, Uwedc.contributor.author
AuthorHenne-Bruns, Dorisdc.contributor.author
AuthorKarstedt, Silvia vondc.contributor.author
AuthorLemke, Johannesdc.contributor.author
Date of accession2021-03-01T14:31:18Zdc.date.accessioned
Available in OPARU since2021-03-01T14:31:18Zdc.date.available
Date of first publication2019-03-30dc.date.issued
AbstractIn the late 1990s, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF-family, started receiving much attention for its potential in cancer therapy, due to its capacity to induce apoptosis selectively in tumour cells in vivo. TRAIL binds to its membrane-bound death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5) inducing the formation of a death-inducing signalling complex (DISC) thereby activating the apoptotic cascade. The ability of TRAIL to also induce apoptosis independently of p53 makes TRAIL a promising anticancer agent, especially in p53-mutated tumour entities. Thus, several so-called TRAIL receptor agonists (TRAs) were developed. Unfortunately, clinical testing of these TRAs did not reveal any significant anticancer activity, presumably due to inherent or acquired TRAIL resistance of most primary tumour cells. Since the potential power of TRAIL-based therapies still lies in TRAIL’s explicit cancer cell-selectivity, a desirable approach going forward for TRAIL-based cancer therapy is the identification of substances that sensitise tumour cells for TRAIL-induced apoptosis while sparing normal cells. Numerous of such TRAIL-sensitising strategies have been identified within the last decades. However, many of these approaches have not been verified in animal models, and therefore potential toxicity of these approaches has not been taken into consideration. Here, we critically summarise and discuss the status quo of TRAIL signalling in cancer cells and strategies to force tumour cells into undergoing apoptosis triggered by TRAIL as a cancer therapeutic approach. Moreover, we provide an overview and outlook on innovative and promising future TRAIL-based therapeutic strategies.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordTRAIL signallingdc.subject
KeywordTRAIL sensitisingdc.subject
KeywordTRAIL-induced apoptosisdc.subject
KeywordTRAIL in cancerdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHTNF-related apoptosis-inducing liganddc.subject.mesh
MeSHTumor necrosis factorsdc.subject.mesh
TitleTRAILblazing strategies for cancer treatmentdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-35519dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-35581-2dc.identifier.urn
GNDTumor-Nekrose-Faktordc.subject.gnd
GNDApoptosisdc.subject.gnd
InstitutionUKU. Klinik für Allgemein- und Viszeralchirurgieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withChristian-Albrechts-Universität zu Kieluulm.cooperation
In cooperation withUniversitätsklinikum Schleswig-Holsteinuulm.cooperation
In cooperation withUniversitätsklinikum Kölnuulm.cooperation
In cooperation withUniversität zu Kölnuulm.cooperation
DOI of original publication10.3390/cancers11040456dc.relation1.doi
Source - Title of sourceCancerssource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume11source.volume
Source - Issue4source.issue
Source - Year2019source.year
Source - Article number456source.articleNumber
Source - eISSN2072-6694source.identifier.eissn
FundingDeutsche Forschungsgemeinschaftuulm.funding
FundingMax-Eder-Nachwuchsgruppenprogramm / Deutsche Krebshilfeuulm.funding
WoS000467773400024uulm.identifier.wos
Bibliographyuulmuulm.bibliographie


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