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AutorHeimrath, Johannadc.contributor.author
Aufnahmedatum2016-03-15T10:41:52Zdc.date.accessioned
In OPARU verfügbar seit2016-03-15T10:41:52Zdc.date.available
Jahr der Erstellung2014dc.date.created
ZusammenfassungAmyotrophic lateral sclerosis (ALS) is characterised by progressive neuronal loss in primary motor cortex. Structural and functional changes in cortical networks have been described in the course of ALS. This study aimed at investigating compensatory neuronal processes in ALS for imagery and observation of movements of everyday life. Additionally, possible differences between ALS patients and controls in white matter integrity and in intrinsic functional connectivity were explored. Twelve ALS patients and 12 healthy controls were measured with functional magnetic resonance imaging (fMRI) during imagery and observation of 12 different movements of body parts and 1 movement of an object. Additionally, resting-state fMRI and diffusion tensor imaging data were acquired and a comprehensive neuropsychological battery was performed. Patients showed more cerebral activity than healthy controls in higher visual, motor, and association areas only for observation of movements that ALS patients are still able to execute in later disease stages. Patients displayed increased activity in the visual cortex only for visual imagery of the object movement and reduced activity for kinaesthetic imagery of body movements. More pronounced motor impairment was associated with higher cerebral activity for observation and imagery. In resting-state fMRI, patients showed increased functional connectivity compared to controls within parahippocampal and parietal areas of the default mode network (DMN). Stronger connectivity within these regions was associated with worse performance in verbal fluency and attention. Apart from the pyramidal tract, patients’ white matter integrity was reduced in frontal areas. ALS patients’ compensatory activity during movement observation and imagery and their increased connectivity within the DMN might represent cortical reorganisation in the sense of recruitment of accessory brain regions to compensate for dysfunctional motor and prefrontal networks.dc.description.abstract
Sprachededc.language.iso
Verbreitende StelleUniversität Ulmdc.publisher
LizenzStandard (ohne Print-On-Demand)dc.rights
Link zum Lizenztexthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
SchlagwortKortikale Reorganisationdc.subject
DDC-SachgruppeDDC 610 / Medicine & healthdc.subject.ddc
MeSHAmyotrophic lateral sclerosisdc.subject.mesh
MeSHMagnetic resonance imagingdc.subject.mesh
MeSHMovement; Physiologydc.subject.mesh
TitelVorstellung und Beobachtung von Alltagsbewegungen bei der Amyotrophen Lateralsklerose: eine multimodale Studie mittels Magnetresonanztomografiedc.title
RessourcentypDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-3515dc.identifier.doi
PPN422794929dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-93475dc.identifier.urn
GNDBewegungsbeobachtungdc.subject.gnd
GNDBewegungsvorstellungdc.subject.gnd
GNDFunktionelle Kernspintomographiedc.subject.gnd
GNDMyatrophische Lateralsklerosedc.subject.gnd
FakultätMedizinische Fakultätuulm.affiliationGeneral
Datum der Freischaltung2014-12-04T13:33:55Zuulm.freischaltungVTS
Peer-Reviewneinuulm.peerReview
Signatur DruckexemplarW: W-H 13.896uulm.shelfmark
DCMI MedientypTextuulm.typeDCMI
VTS-ID9347uulm.vtsID
KategoriePublikationenuulm.category


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