Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment
Wissenschaftlicher Artikel
Authors
Riegger, Jana
Brenner, Rolf E.
Institutions
UKU. Klinik für OrthopädiePublished in
International Journal of Molecular Sciences ; 21 (2020). - Art.-Nr. 1560. - ISSN 1661-6596. - eISSN 1422-0067
Link to original publication
https://dx.doi.org/10.3390/ijms21051560Peer review
ja
Document version
publishedVersion
Abstract
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These pathogenetic
processes include oxidative stress, excessive expression of catabolic enzymes, release of
damage-associated molecular patterns (DAMPs), and synovial inflammation. The present review
focuses on the underlying pathomechanisms of PTOA and in particular the behavior and fate of the
surviving chondrocytes, comprising chondrocyte metabolism, regulated cell death, and phenotypical
changes comprising hypertrophy and senescence. Moreover, possible therapeutic strategies, such
as chondroanabolic stimulation, anti-oxidative and anti-inflammatory treatment, as well as novel
therapeutic targets are discussed.
Subject Headings
Osteoarthritis [GND]Kniegelenk [GND]
Entzündung [GND]
Pathomechanismus [GND]
Osteoarthritis; Therapy [MeSH]
Oxidative stress [MeSH]
Cell death [MeSH]
Metabolism [MeSH]
Chondrocytes [MeSH]
Keywords
Posttraumatic osteoarthritis; DAMP release; Synovial inflammation; CSPC; Catabolism; AnabolismDewey Decimal Group
DDC 610 / Medicine & healthMetadata
Show full item recordCitation example
Riegger, Jana; Brenner, Rolf E. (2021): Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment. Open Access Repositorium der Universität Ulm. http://dx.doi.org/10.18725/OPARU-35302