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Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment

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Brenner_2020_1.pdf (678.4Kb)

peer-reviewed

Erstveröffentlichung
2020-01-18
Authors
Riegger, Jana
Brenner, Rolf E.
Wissenschaftlicher Artikel


Published in
International Journal of Molecular Sciences ; 21 (2020). - Art.-Nr. 1560. - ISSN 1661-6596. - eISSN 1422-0067
Link to original publication
https://dx.doi.org/10.3390/ijms21051560
Institutions
UKU. Klinik für Orthopädie
Document version
published version (publisher's PDF)
Abstract
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These pathogenetic processes include oxidative stress, excessive expression of catabolic enzymes, release of damage-associated molecular patterns (DAMPs), and synovial inflammation. The present review focuses on the underlying pathomechanisms of PTOA and in particular the behavior and fate of the surviving chondrocytes, comprising chondrocyte metabolism, regulated cell death, and phenotypical changes comprising hypertrophy and senescence. Moreover, possible therapeutic strategies, such as chondroanabolic stimulation, anti-oxidative and anti-inflammatory treatment, as well as novel therapeutic targets are discussed.
Subject headings
[GND]: Osteoarthritis | Kniegelenk | Entzündung | Pathomechanismus
[MeSH]: Osteoarthritis; Therapy | Oxidative stress | Cell death | Metabolism | Chondrocytes
[Free subject headings]: Posttraumatic osteoarthritis | DAMP release | Synovial inflammation | CSPC | Catabolism | Anabolism
[DDC subject group]: DDC 610 / Medicine & health
License
CC BY 4.0 International
https://creativecommons.org/licenses/by/4.0/

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-35302

Riegger, Jana; Brenner, Rolf E. (2021): Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-35302
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