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AuthorYilmazer-Hanke, Denizdc.contributor.author
AuthorMayer, Theresadc.contributor.author
AuthorMüller, Hans-Peterdc.contributor.author
AuthorNeugebauer, Hermanndc.contributor.author
AuthorAbaei, Alirezadc.contributor.author
AuthorScheuerle, Angelikadc.contributor.author
AuthorWeis, Joachimdc.contributor.author
AuthorForsberg, Karin M.E.dc.contributor.author
AuthorAlthaus, Katharinadc.contributor.author
AuthorMeier, Juliadc.contributor.author
AuthorLudolph, Albert C.dc.contributor.author
AuthorDel Tredici, Kellydc.contributor.author
AuthorBraak, Heikodc.contributor.author
AuthorKassubek, Jan Rainerdc.contributor.author
AuthorRasche, Volkerdc.contributor.author
Date of accession2021-02-16T13:19:15Zdc.date.accessioned
Available in OPARU since2021-02-16T13:19:15Zdc.date.available
Date of first publication2020-03-13dc.date.issued
AbstractThe identification of cerebral microinfarctions with magnetic resonance imaging (MRI) and histological methods remains challenging in aging and dementia. Here, we matched pathological changes in the microvasculature of cortical cerebral microinfarcts to MRI signals using single 100 μm-thick histological sections scanned with ultra-highresolution 11.7 T MRI. Histologically, microinfarcts were located in superficial or deep cortical layers or transcortically, compatible with the pattern of layer-specific arteriolar blood supply of the cerebral cortex. Contrary to acute microinfarcts, at chronic stages the core region of microinfarcts showed pallor with extracellular accumulation of lipofuscin and depletion of neurons, a dense meshwork of collagen 4-positive microvessels with numerous string vessels, CD68-positive macrophages and glial fibrillary acidic protein (GFAP)-positive astrocytes. In MRI scans, cortical microinfarcts at chronic stages, called chronic cortical microinfarcts here, gave hypointense signals in T1-weighted and hyperintense signals in T2-weighted images when thinning of the tissue and cavitation and/or prominent iron accumulation were present. Iron accumulation in chronic microinfarcts, histologically verified with Prussian blue staining, also produced strong hypointense T2*-weighted signals. In summary, the microinfarct core was occupied by a dense microvascular meshwork with string vessels, which was invaded by macrophages and astroglia and contained various degrees of iron accumulation. While postmortem ultra-high-resolution single-section imaging improved MRI-histological matching and the structural characterization of chronic cortical cerebral microinfarcts, miniscule microinfarcts without thinning or iron accumulation could not be detected with certainty in the MRI scans. Moreover, string vessels at the infarct margin indicate disturbances in the microcirculation in and around microinfarcts, which might be exploitable in the diagnostics of cortical cerebral microinfarcts with MRI in vivo.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordPost-mortem magnetic resonance imagingdc.subject
KeywordHistological matchingdc.subject
KeywordMicrobleedsdc.subject
KeywordString vesselsdc.subject
KeywordCerebral microangiopathydc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHCerebral small vessel diseasesdc.subject.mesh
MeSHMagnetic resonance imagingdc.subject.mesh
TitleHistological correlates of postmortem ultrahigh-resolution single-section MRI incortical cerebral microinfarctsdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-35126dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-35188-0dc.identifier.urn
GNDKernspintomografiedc.subject.gnd
GNDMikroangiopathiedc.subject.gnd
InstitutionUKU. Klinik für Neurologieuulm.affiliationSpecific
InstitutionZentrum für Translationale Bildgebung (MoMan)uulm.affiliationSpecific
InstitutionUKU. Klinik für Innere Medizin IIuulm.affiliationSpecific
InstitutionUKU. Institut für Pathologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withUniversitätsklinikum Aachenuulm.cooperation
In cooperation withUmeå Universityuulm.cooperation
Is Supplemented Byhttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-00900-1#Sec16uulm.relation.isSupplementedBy
DOI of original publication10.1186/s40478-020-00900-1dc.relation1.doi
Source - Title of sourceActa Neuropathologica Communicationssource.title
Source - Place of publicationBMCsource.publisher
Source - Volume8source.volume
Source - Year2020source.year
Source - Article number33source.articleNumber
Source - eISSN2051-5960source.identifier.eissn
FundingCorona Stiftunguulm.funding
FundingAlzheimer's and Dementiauulm.funding
University Bibliographyjauulm.unibibliographie


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CC BY 4.0 International
Except where otherwise noted, this item's license is described as CC BY 4.0 International