Characterization of the ProSAP1/Shank2 knock-out mouse
RefereeBöckers, Tobias M.
InstitutionsInstitut für Anatomie und Zellbiologie
Proline-rich synapse- associated (ProSAP)/ SH3 and ankyrin repeats containing (Shank) proteins are located in deeper parts of the post-synaptic density in excitatory neurons, where they act as master-scaffolding molecules. The protein family consists of three members: ProSAP1/Shank2, ProSAP2/Shank3 and ProSAP3/Shank1, which are differently distributed throughout the brain. Mutations within these proteins have been associated with neurodevelopmental and neuropsychiatric disorders in human patients, including autism-spectrum disorders, intellectual disability, schizophrenia and bipolar disorder. To gain insight into the pathophysiology of these conditions, several knock-out mouse lines were generated throughout the world. The first of these mutant lines is presented here, called ProSAP1/Shank2(Δex7) KO which was shown to present autism-like behaviour and hyperactivity.
Subject headings[GND]: Knockout <Molekulargenetik> | Spine | Synapse | Autismus
[MeSH]: Mice, Knockout | Dendritic spines | Synapses | Post-synaptic density | Autism spectrum disorder
[Free subject headings]: ProSAP1 | Shank2 | Knock-out mouse | Autism mouse model | PSD
[DDC subject group]: DDC 610 / Medicine & health
LicenseStandard (ohne Print-on-Demand)
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DOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-34967