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AuthorRiegger, Janadc.contributor.author
AuthorRehm, Martindc.contributor.author
AuthorBüchele, Giseladc.contributor.author
AuthorBrenner, Hermanndc.contributor.author
AuthorGünther, Klaus-Peterdc.contributor.author
AuthorRothenbacher, Dietrichdc.contributor.author
AuthorBrenner, Rolf E.dc.contributor.author
Date of accession2021-02-02T08:37:32Zdc.date.accessioned
Available in OPARU since2021-02-02T08:37:32Zdc.date.available
Date of first publication2020-01-18dc.date.issued
AbstractThis study aimed to assess associations between serum cartilage oligomeric matrix protein (sCOMP) and phenotypic characteristics in late-stage hip and knee Osteoarthritis (OA) as well as its correlation with further serum markers of possible comorbidities in the Ulm Osteoarthritis Study. Moreover, the prognostic relevance of preoperative sCOMP concentrations for short-term functionality and pain outcomes after hip or knee joint replacement was explored. Preoperative serum samples and detailed information about the health status (i.e., WOMAC scores, Hannover Functionality Status (FFbH)) of 754 OA patients undergoing total joint replacement were included. Spearman rank-correlation coe cients and multiple linear regression models were used to evaluate the relationships between sCOMP, other serum markers, and health outcomes. There was a significant positive association between sCOMP and markers of renal (cystatin C, creatinine, and eGFR) and cardiac (e.g., NT-proBNP) impairment. Since renal failure might cause accumulation of sCOMP, additional adjustment with eGFR was performed. Preoperative sCOMP levels in knee OA but not hip OA patients were positively associated with FFbH, WOMAC function sub-scale and total WOMAC scale as well as the post-operative WOMAC sti ness sub-scale six months after surgery. Our data clearly demonstrate an association between sCOMP and renal function as well as other confounding factors, which should be considered in future biomarker studiesdc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordCOMPdc.subject
KeywordRenal functiondc.subject
KeywordNT-proBNPdc.subject
KeywordWOMACdc.subject
KeywordFFbHdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHOsteoarthritis, Kneedc.subject.mesh
MeSHOsteoarthritis, Hipdc.subject.mesh
MeSHComorbiditydc.subject.mesh
MeSHKidneydc.subject.mesh
MeSHCystatin Cdc.subject.mesh
MeSHBiomarkersdc.subject.mesh
TitleSerum cartilage oligomeric matrix protein in late-stage osteoarthritis: association with clinical features, renal function, and cardiovascular biomarkersdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-34841dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-34903-8dc.identifier.urn
GNDOsteoarthritisdc.subject.gnd
GNDKniegelenkdc.subject.gnd
GNDHüftgelenkarthrosedc.subject.gnd
GNDSekundärkrankheitdc.subject.gnd
GNDBiomarkerdc.subject.gnd
GNDNierenfunktiondc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Klinik für Orthopädieuulm.affiliationSpecific
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withDeutsches Krebsforschungszentrum in der Helmholtz-Gemeinschaftuulm.cooperation
In cooperation withUniversität Heidelberguulm.cooperation
In cooperation withTechnische Universität Dresdenuulm.cooperation
DOI of original publication10.3390/jcm9010268dc.relation1.doi
Source - Title of sourceJournal of Clinical Medicinesource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume9source.volume
Source - Year2020source.year
Source - Article number268source.articleNumber
Source - eISSN2077-0383source.identifier.eissn
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttp://www.mdpi.com/2077-0383/9/1/268/s1dc.relation.isSupplementedBy
xmlui.metadata.uulm.OAfundingOpen-Access-Förderung durch die Medizinische Fakultät der Universität Ulmuulm.OAfunding


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