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AuthorŞenel, Makbuledc.contributor.author
AuthorRapp, Danieldc.contributor.author
AuthorMayer, Benjamindc.contributor.author
AuthorJesse, Sarahdc.contributor.author
AuthorSüßmuth, Sigurddc.contributor.author
AuthorOtto, Markusdc.contributor.author
AuthorLewerenz, Jandc.contributor.author
AuthorTumani, Hayrettindc.contributor.author
Date of accession2021-01-26T12:44:39Zdc.date.accessioned
Available in OPARU since2021-01-26T12:44:39Zdc.date.available
Date of first publication2020-09-25dc.date.issued
AbstractTo investigate whether and how cerebrospinal fluid (CSF) findings can contribute to distinguish tick-borne encephalitis (TBE) from herpes simplex virus (HSV) and varicella zoster virus (VZV) induced central nervous system (CNS) infections (HSV-I, VZV-I). Chart review and identification of TBE, HSV- I, and VZV-I was carried out, fulfilling the following criteria: (1) clinical signs of encephalitis and/or meningitis, (2) complete CSF analysis and confirmed viral etiology by either PCR or antibody testing in CSF, (3) hospitalized patients, and (4) available brain magnetic resonance imaging (MRI). Fifty-nine patients with 118 CSF/serum pairs were included. These comprised 21 with TBE (35 CSF/serum pairs), 20 (40 CSF/serum pairs) with HSV-I, and 18 (43 CSF/serum pairs) with VZV-I. In contrast to HSV-I and VZV-I, CSF cell di erentiation in TBE showed more often an increased (>20%) proportion of granulocytes (p < 0.01) and a more frequent quantitative intrathecal IgM synthesis (p = 0.001 and p < 0.01, respectively), while the second was even more pronounced when follow-up CSF analyses were included (p < 0.001). CSF findings help to distinguish TBE from other viral infections. In cases with CSF pleocytosis and a positive history for a stay in or near an endemic area, TBE antibodies in CSF and serum should be determined, especially if granulocytes in CSF cell di erentiation and/or an intrathecal IgM synthesis is present.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
KeywordTBEdc.subject
KeywordTBEVdc.subject
KeywordHSVdc.subject
KeywordVZVdc.subject
KeywordViraldc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHEncephalitisdc.subject.mesh
MeSHEncephalitis, Tick-bornedc.subject.mesh
MeSHMeningitisdc.subject.mesh
TitleTick-borne encephalitis: a differential pattern of intrathecal humoral immune response and inflammatory cell composition compared with other viral CNS infectionsdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-34467dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-34529-0dc.identifier.urn
GNDFrühjahr-Sommer-Encephalitisdc.subject.gnd
GNDHirnhautentzündungdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Klinik für Neurologieuulm.affiliationSpecific
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
InstitutionFachklinik für Neurologie Dietenbronn GmbHuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3390/cells9102169dc.relation1.doi
Source - Title of sourceCellssource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume9source.volume
Source - Year2020source.year
Source - Article number2169;source.articleNumber
Source - eISSN2073-4409source.identifier.eissn
Bibliographyuulmuulm.bibliographie


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