Tick-borne encephalitis: a differential pattern of intrathecal humoral immune response and inflammatory cell composition compared with other viral CNS infections
Wissenschaftlicher Artikel
Authors
Şenel, Makbule
Rapp, Daniel
Mayer, Benjamin
Jesse, Sarah
Süßmuth, Sigurd
Faculties
Medizinische FakultätInstitutions
UKU. Klinik für NeurologieInstitut für Epidemiologie und Medizinische Biometrie
Fachklinik für Neurologie Dietenbronn GmbH
Published in
Cells ; 9 (2020). - Art.-Nr. 2169;. - eISSN 2073-4409
Link to original publication
https://dx.doi.org/10.3390/cells9102169Peer review
ja
Document version
publishedVersion
Abstract
To investigate whether and how cerebrospinal fluid (CSF) findings can contribute to
distinguish tick-borne encephalitis (TBE) from herpes simplex virus (HSV) and varicella zoster
virus (VZV) induced central nervous system (CNS) infections (HSV-I, VZV-I). Chart review and
identification of TBE, HSV- I, and VZV-I was carried out, fulfilling the following criteria: (1) clinical
signs of encephalitis and/or meningitis, (2) complete CSF analysis and confirmed viral etiology by either
PCR or antibody testing in CSF, (3) hospitalized patients, and (4) available brain magnetic resonance
imaging (MRI). Fifty-nine patients with 118 CSF/serum pairs were included. These comprised 21
with TBE (35 CSF/serum pairs), 20 (40 CSF/serum pairs) with HSV-I, and 18 (43 CSF/serum pairs)
with VZV-I. In contrast to HSV-I and VZV-I, CSF cell di erentiation in TBE showed more often an
increased (>20%) proportion of granulocytes (p < 0.01) and a more frequent quantitative intrathecal
IgM synthesis (p = 0.001 and p < 0.01, respectively), while the second was even more pronounced
when follow-up CSF analyses were included (p < 0.001). CSF findings help to distinguish TBE from
other viral infections. In cases with CSF pleocytosis and a positive history for a stay in or near an
endemic area, TBE antibodies in CSF and serum should be determined, especially if granulocytes in
CSF cell di erentiation and/or an intrathecal IgM synthesis is present.
Subject Headings
Frühjahr-Sommer-Encephalitis [GND]Hirnhautentzündung [GND]
Encephalitis [MeSH]
Encephalitis, Tick-borne [MeSH]
Meningitis [MeSH]
Keywords
TBE; TBEV; HSV; VZV; ViralDewey Decimal Group
DDC 610 / Medicine & healthMetadata
Show full item recordCitation example
Şenel, Makbule et al. (2021): Tick-borne encephalitis: a differential pattern of intrathecal humoral immune response and inflammatory cell composition compared with other viral CNS infections. Open Access Repositorium der Universität Ulm. http://dx.doi.org/10.18725/OPARU-34467