Association of lung function with overall mortality is independent of inflammatory cardiac, and functional biomarkers in older adults: the ActiFE‑study

peer-reviewed
Erstveröffentlichung
2020-07-17Authors
Weinmayr, Gudrun
Schulz, Holger
Klenk, Jochen
Denkinger, Michael D.
Duran‑Tauleria, Enric
Wissenschaftlicher Artikel
Published in
Scientific Reports ; 10 (2020). - Art.-Nr. 11862. - eISSN 2045-2322
Link to original publication
https://dx.doi.org/10.1038/s41598-020-68372-wFaculties
Medizinische FakultätInstitutions
Institut für Epidemiologie und Medizinische BiometrieBethesda Geriatrische Klinik Ulm
External cooperations
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und UmweltDeutsches Zentrum für Lungenforschung
Robert-Bosch-Krankenhaus
IB Hochschule Stuttgart
Global Institute of Integral Attention to the Neurodevelopment (IGAIN)
Document version
published version (publisher's PDF)Abstract
Reduced lung function is associated with overall and cardiovascular mortality. Chronic low grade
systemic inflammation is linked to impaired lung function and cardiovascular outcomes. We assessed
the association of lung function with overall 8-year mortality in 867 individuals of the Activity and
Function in the Elderly study using confounder-adjusted Cox proportional hazards models (including
gait speed and daily walking time as measures of physical function) without and with adjustment for
inflammatory and cardiac markers. Forced expiratory volume in 1 s/forced vital capacity (
FEV1/FVC)
but not FVC was related to mortality after adjustment for physical function and other confounders.
Additional adjustment for inflammatory and cardiac markers did not change the hazard ratios (HR)
markedly, e.g. for a FEV1/
FVC below 0.7 from 1.55 [95% confidence-interval (CI) 1.14–2.11] to 1.49
(95% CI 1.09–2.03). These independent associations were also observed in the apparently lung healthy
subpopulation with even higher HRs up to 2.76 (95% CI 1.52–4.93). A measure of airflow limitation but
not vital capacity was associated with overall mortality in this community-dwelling older population
and in the subgroup classified as lung healthy. These associations were independent of adjustment for
inflammatory and cardiac markers and support the role of airflow limitation as independent predictor
of mortality in older adults.
Publication funding
Gefördert vom Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
Open-Access-Förderung durch die Medizinische Fakultät der Universität Ulm
Open-Access-Förderung durch die Medizinische Fakultät der Universität Ulm
Is supplemented by
https://www.nature.com/articles/s41598-020-68372-w#Sec17Subject headings
[GND]: Herzkrankheit | Atemwegskrankheit | Lungenfunktion | Biomarker[MeSH]: Lung diseases | Cardiovascular diseases | Respiratory tract diseases | Risk factors | Biomarkers | Inflammation
[Free subject headings]: Cardiology | Epidemiology | Predictive markers
[DDC subject group]: DDC 610 / Medicine & health
Metadata
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-34396
Weinmayr, Gudrun et al. (2021): Association of lung function with overall mortality is independent of inflammatory cardiac, and functional biomarkers in older adults: the ActiFE‑study. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-34396
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