Association of lung function with overall mortality is independent of inflammatory cardiac, and functional biomarkers in older adults: the ActiFE‑study
Wissenschaftlicher Artikel
Authors
Weinmayr, Gudrun
Schulz, Holger
Klenk, Jochen
Denkinger, Michael D.
Duran‑Tauleria, Enric
Faculties
Medizinische FakultätInstitutions
Institut für Epidemiologie und Medizinische BiometrieBethesda Geriatrische Klinik Ulm
External cooperations
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und UmweltDeutsches Zentrum für Lungenforschung
Robert-Bosch-Krankenhaus
IB Hochschule Stuttgart
Global Institute of Integral Attention to the Neurodevelopment (IGAIN)
Published in
Scientific Reports ; 10 (2020). - Art.-Nr. 11862. - eISSN 2045-2322
Link to original publication
https://dx.doi.org/10.1038/s41598-020-68372-wPeer review
ja
Document version
publishedVersion
Abstract
Reduced lung function is associated with overall and cardiovascular mortality. Chronic low grade
systemic inflammation is linked to impaired lung function and cardiovascular outcomes. We assessed
the association of lung function with overall 8-year mortality in 867 individuals of the Activity and
Function in the Elderly study using confounder-adjusted Cox proportional hazards models (including
gait speed and daily walking time as measures of physical function) without and with adjustment for
inflammatory and cardiac markers. Forced expiratory volume in 1 s/forced vital capacity (
FEV1/FVC)
but not FVC was related to mortality after adjustment for physical function and other confounders.
Additional adjustment for inflammatory and cardiac markers did not change the hazard ratios (HR)
markedly, e.g. for a FEV1/
FVC below 0.7 from 1.55 [95% confidence-interval (CI) 1.14–2.11] to 1.49
(95% CI 1.09–2.03). These independent associations were also observed in the apparently lung healthy
subpopulation with even higher HRs up to 2.76 (95% CI 1.52–4.93). A measure of airflow limitation but
not vital capacity was associated with overall mortality in this community-dwelling older population
and in the subgroup classified as lung healthy. These associations were independent of adjustment for
inflammatory and cardiac markers and support the role of airflow limitation as independent predictor
of mortality in older adults.
Funding information
IMCA II / European Commission [2005121]
DFG [RO2606/14-1]
DFG [DE2674/1-1]
Gefördert vom Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
DFG [RO2606/14-1]
DFG [DE2674/1-1]
Gefördert vom Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
Is supplemented by
https://www.nature.com/articles/s41598-020-68372-w#Sec17Subject Headings
Herzkrankheit [GND]Atemwegskrankheit [GND]
Lungenfunktion [GND]
Biomarker [GND]
Lung diseases [MeSH]
Cardiovascular diseases [MeSH]
Respiratory tract diseases [MeSH]
Risk factors [MeSH]
Biomarkers [MeSH]
Inflammation [MeSH]
Keywords
Cardiology; Epidemiology; Predictive markersDewey Decimal Group
DDC 610 / Medicine & healthMetadata
Show full item recordCitation example
Weinmayr, Gudrun et al. (2021): Association of lung function with overall mortality is independent of inflammatory cardiac, and functional biomarkers in older adults: the ActiFE‑study. Open Access Repositorium der Universität Ulm. http://dx.doi.org/10.18725/OPARU-34396