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The emerging role of exosomes in diagnosis, prognosis, and therapy in head and neck cancer

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peer-reviewed

Erstveröffentlichung
2020-06-06
Authors
Hofmann, Linda
Ludwig, Sonja
Vahl, Julius M.
Brunner, Cornelia
Hoffmann, Thomas K.
et al.
Wissenschaftlicher Artikel


Published in
International Journal of Molecular Sciences ; 21 (2020), 11. - Art.-Nr. 4072. - ISSN 1661-6596. - eISSN 1422-0067
Link to original publication
https://dx.doi.org/10.3390/ijms21114072
Institutions
UKU. Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie
External cooperations
Universitätsmedizin Mannheim
Document version
published version (publisher's PDF)
Abstract
Exosomes, the smallest group of extracellular vesicles, carry proteins, miRNA, mRNA, DNA, and lipids, which they efficiently deliver to recipient cells, generating a communication network. Exosomes strongly contribute to the immune suppressive tumor microenvironment of head and neck squamous cell carcinomas (HNSCC). Isolation of exosomes from HNSCC cell culture or patient’s plasma allows for analyzing their molecular cargo and functional role in immune suppression and tumor progression. Immune affinity-based separation of different exosome subsets, such as tumor-derived or T cell-derived exosomes, from patient’s plasma simultaneously informs about tumor status and immune dysfunction. In this review, we discuss the recent understanding of how exosomes behave in the HNSCC tumor microenvironment and why they are promising liquid biomarkers for diagnosis, prognosis, and therapy in HNSCC.
Publication funding
Gefördert vom Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
Open-Access-Förderung durch die Medizinische Fakultät der Universität Ulm
Subject headings
[GND]: Plattenepithelcarcinom | Exosom <Vesikel> | Biomarker
[MeSH]: Squamous cell carcinoma of head and neck | Exosomes | Biomarkers
[Free subject headings]: HNSCC | Liquid biomarker | Tumor microenvironment
[DDC subject group]: DDC 610 / Medicine & health
License
CC BY 4.0 International
https://creativecommons.org/licenses/by/4.0/

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-34392

Hofmann, Linda et al. (2021): The emerging role of exosomes in diagnosis, prognosis, and therapy in head and neck cancer. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-34392
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