Comparison of MDRD, CKD-EPI, and Cockcroft-Gault equation in relation to measured glomerular filtration rate among a large cohort with diabetes
Wissenschaftlicher Artikel
Authors
Schwandt, Anke
Denkinger, Michael D.
Fasching, Peter
Pfeifer, Martin
Wagner, Christian
Faculties
Medizinische FakultätInstitutions
Institut für Epidemiologie und Medizinische BiometrieGeriatrisches Zentrum Ulm/Alb-Donau
External cooperations
Wilhelminenspital WienDeutsches Zentrum für Diabetesforschung (DZD)
Diabeteszentrum - Medizin Campus Bodensee
Kreisklinik Bad Reichenhall
Sana Hospital Bethesda Stuttgart
Published in
Journal of Diabetes and its Complications ; 31 (2017), 9. - S. 1376-1383. - ISSN 1056-8727. - eISSN 1873-460X
Link to original publication
https://dx.doi.org/10.1016/j.jdiacomp.2017.06.016Peer review
ja
Document version
acceptedVersion
Abstract
Aims: To analyze the performance of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft-Gault (CG), and CG calculated with ideal bodyweight (CG-IBW) equations to estimate glomerular filtration rate (eGFR) based on serum creatinine in a large diabetic population.
Methods: 24,516 adults with type-1-diabetes or type-2-diabetes from the multicenter diabetes prospective follow-up registry DPV were analyzed. We compared eGFR and measured GFR (mGFR) based on 24-h urine collection by calculating mean bias (difference), precision (SD of this difference), accuracy (proportion of eGFR within ±10% of mGFR), Bland-Altman-plots.
Results: CG overestimates, whereas MDRD, CKD-EPI, and CG-IBW underestimate. Smallest mean bias and highest accuracy (75.3%) were observed for MDRD compared to the other equations (p<0.0001). MDRD and CKD-EPI estimated most accurately in stages 1 (MDRD:57.7%, CKD-EPI:57.3%) and 2 (MDRD:80.2%, CKD-EPI:80.7%). In stages 3 to 5, highest accuracy was observed for the MDRD (stage3:82.3%, stage4:77.8%, stage5:71.0%). Among younger subjects, accuracy was higher using the CKD-EPI (18-<40 years:63.7%, 40-<60 years:72.8%). Above age 60 years, MDRD estimated most accurately (60-<70 years:77.3%, ≥70 years:78.8%). In males and females, MDRD estimated most accurately (males:75.3%, females:75.3%).
Conclusion: In this large diabetic cohort, smallest bias and highest accuracy were observed for the MDRD.
Funding information
Kompetenznetz Diabetes mellitus (Competence Network for Diabetes Mellitus) / BMBF [01GI1106]
Deutsches Zentrum für Diabetesforschung (DZD)
Leona M. and Harry B. Helmsley Charitable Trust
European Federation of Pharmaceutical Industries and Associations
JDRF
etc.
Deutsches Zentrum für Diabetesforschung (DZD)
Leona M. and Harry B. Helmsley Charitable Trust
European Federation of Pharmaceutical Industries and Associations
JDRF
etc.
EU Project
INNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 115797 / EC / H2020 / 115797
Subject Headings
Diabetes mellitus Typ 1 [GND]Diabetes mellitus Typ 2 [GND]
Nierenkrankheit [GND]
Nierenfunktion [GND]
Diabetes mellitus, Type 1 [MeSH]
Diabetes mellitus, Type 2 [MeSH]
Glomerular filtration rate [MeSH]
Renal insufficiency, Chronic [MeSH]
Keywords
Modification of diet in renal disease (MDRD); Chronic kidney disease epidemiology collaboration (CKD-EPI); Cockcroft-gault (CG); Renal-function; Serum creatinineMetadata
Show full item recordCitation example
Schwandt, Anke et al. (2021): Comparison of MDRD, CKD-EPI, and Cockcroft-Gault equation in relation to measured glomerular filtration rate among a large cohort with diabetes. Open Access Repositorium der Universität Ulm. http://dx.doi.org/10.18725/OPARU-34175
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